# The role of systemic inflammation in patients with conjunctivochalasis

## TL;DR

This study found that conjunctivochalasis may be linked to systemic inflammation, as shown by higher monocyte-to-HDL ratios and lower hemoglobin levels in affected patients.

## Contribution

This is the first study to show an elevated monocyte-to-HDL ratio in conjunctivochalasis patients, suggesting a systemic inflammatory link.

## Key findings

- The monocyte-to-HDL ratio was significantly higher in conjunctivochalasis patients compared to healthy controls.
- Hemoglobin levels were significantly lower in patients with conjunctivochalasis.
- No significant differences were found in other blood or lipid parameters between the groups.

## Abstract

To compare systemic inflammation parameters and blood lipid profile in patients with conjunctivochalasis versus healthy individuals.

Thirty patients with conjunctivochalasis(Cch) and thirty age-matched healthy controls were included in this retrospective study. Complete blood count (CBC) parameters and serum levels of total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) were obtained from electronic medical records. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-HDL ratio (MHR) were calculated for each participant. Group differences were analyzed statistically.

The monocyte-to-HDL ratio was significantly higher in the conjunctivochalasis group (p = 0.023), while hemoglobin levels were significantly lower (p = 0.001). No additional significant differences were observed in other hematological or lipid parameters.

This study is the first to demonstrate an elevated monocyte-to-HDL ratio in patients with conjunctivochalasis. The concurrent reduction in hemoglobin levels provides further support for a potential systemic association. These findings suggest that conjunctivochalasis may involve not only localized ocular changes but also systemic inflammatory processes.

Conjunctivochalasis is associated with age-related ocular surface changes and localized inflammation.

Conjunctivochalasis is associated with age-related ocular surface changes and localized inflammation.

This is the first study demonstrating significantly increased monocyte-to-HDL ratio (MHR) in patients with conjunctivochalasis.Hemoglobin levels were significantly lower in conjunctivochalasis patients compared with controls.These findings suggest a potential systemic inflammatory component in the pathogenesis of conjunctivochalasis.

This is the first study demonstrating significantly increased monocyte-to-HDL ratio (MHR) in patients with conjunctivochalasis.

Hemoglobin levels were significantly lower in conjunctivochalasis patients compared with controls.

These findings suggest a potential systemic inflammatory component in the pathogenesis of conjunctivochalasis.