# Lower fat-free mass is independently linked to restless legs syndrome in men: a cross-sectional PSG–BIA study

## TL;DR

Lower muscle mass is linked to restless legs syndrome in men, suggesting muscle health may play a role in the condition's development.

## Contribution

This study identifies a male-specific association between reduced fat-free mass and RLS, using PSG and BIA data.

## Key findings

- RLS prevalence was higher in males with sarcopenia compared to those without.
- Lower fat-free mass index was independently associated with RLS in men.
- Sex-specific effects were observed, with significant interactions for FFMI in males.

## Abstract

Restless legs syndrome (RLS) is a common sensorimotor disorder that disrupts sleep and quality of life. Sarcopenia—reduced skeletal muscle mass and function—has been linked to sleep disturbances, but its relationship with RLS remains unclear. We examined whether sarcopenia is associated with RLS, with a focus on sex-specific effects.

We conducted a cross-sectional analysis of 5,752 adults who underwent both type-I polysomnography (PSG) and bioelectrical impedance analysis (BIA) at a tertiary sleep center. RLS was diagnosed by IRLSSG criteria. Sarcopenia was defined using skeletal muscle index (SMI) and fat-free mass index (FFMI) thresholds. Multivariable models adjusted for age, physical activity, caffeine/alcohol intake, and apnea–hypopnea index (AHI).

RLS prevalence was 6.6% in females and 2.9% in males. Sarcopenia was more frequent in the RLS group than in non-RLS (10.6 vs. 6.8%), particularly among males (8.7 vs. 3.2%). In males, lower SMI and FFMI were independently associated with higher odds of RLS; sex interaction for FFMI was significant.

Reduced muscle mass is independently associated with RLS in men, suggesting a male-specific muscle phenotype relevant to RLS pathophysiology. Incorporating BIA-based screening and muscle-preserving interventions may benefit the management of male patients with RLS.