# Correlation analysis of coagulation factor level and chronic low-grade inflammation in patients with type 2 diabetes mellitus complicated with ischemic stroke

## TL;DR

This study found that T2DM patients with ischemic stroke have altered coagulation and higher inflammation levels, which could help improve personalized treatment strategies.

## Contribution

The study identifies specific correlations between inflammatory markers and coagulation indicators in T2DM patients with ischemic stroke.

## Key findings

- IL-6 was negatively correlated with APTT and PT, and positively with fibrinogen in T2DM patients with ischemic stroke.
- T2DM patients with ischemic stroke showed significantly elevated inflammatory markers and altered coagulation parameters compared to controls.
- Monitoring inflammatory markers may improve thrombosis prevention and treatment precision in T2DM patients.

## Abstract

To analyze differences in coagulation function and plasma inflammatory factors between type 2 diabetes mellitus (T2DM) patients with and without ischemic stroke (IS), and explore related mechanisms.

50 patients with T2DM complicated with IS (experimental group, EG) and 50 patients with simple T2DM (control group, CG) were retrospectively included, while 30 healthy volunteers served as the blank group (BG). The expression levels of plasma interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and nuclear factor-κB (NF-κB) in the EG were significantly elevated as against the CG and the BG (p<0.05).

As against the CG and the BG, activated partial thromboplastin time (APTT) and prothrombin time (PT) levels were significantly reduced, while the plasma fibrinogen (FIB) and D-Dimer (DD) levels were significantly elevated in the EG; The incidence of postoperative complications in the EG (13.46 %) was significantly reduced as against the CG (21.15 %) (p<0.05). IL-6 was notably negatively correlated with APTT (p=0.002, r=−0.432); it was extremely significantly negatively correlated with PT (p=0.000, r=−0.536); it was notably positively correlated with plasma FIB content (p=0.001, r=0.445).

The coagulation function and peripheral blood inflammatory markers in patients with T2DM complicated by IS were significantly different compared to those in patients with T2DM alone and healthy volunteers. The correlation between inflammatory markers and coagulation indicators (e.g., the negative correlation between IL-6 and APTT/PT) identified in this study holds important clinical significance. It provides new insights for thrombosis risk stratification and personalized antithrombotic treatment in T2DM patients. Monitoring the levels of inflammatory markers may optimize thrombosis prevention strategies and enhance the precision of clinical diagnosis and treatment.