# An entropy-initiated coupled-trait ODE framework for modeling longitudinal cohort dynamics

**Authors:** Anderson M. Rodriguez, Mario Treviño Villegas, Mario Treviño Villegas, Mario Treviño Villegas

PMC · DOI: 10.1371/journal.pone.0344090 · PLOS One · 2026-03-19

## TL;DR

This paper introduces a new framework using entropy and ordinary differential equations to model longitudinal cohort data, showing it can capture major trends without complex assumptions.

## Contribution

The novel ECTO framework uses entropy to initialize low-dimensional dynamics for modeling cohort-level longitudinal data.

## Key findings

- ECTO reproduces cohort-level trajectories using entropy-initialized ODEs.
- The framework achieves stable out-of-sample performance across different datasets.
- Entropy serves as a summary of heterogeneity rather than a dynamical driver.

## Abstract

This work introduces a minimal, information-theoretic dynamical framework for modeling longitudinal cohort data using an entropy-initiated system of coupled-trait ordinary differential equations (ECTO). For each survey wave, item-level Likert responses are compressed into a normalized Shannon entropy index that summarizes cross-sectional dispersion; this index is used to initialize the low-dimensional state variables of the autonomous ODE system. ECTO then tracks the interactions among a primary trait-like state, a secondary coupled state, and a latent environmental-stress component through phenomenological terms representing generic self-limitation, trade-offs, and feedback. Using data from the Swedish Adoption/Twin Study on Aging (SATSA), the framework reproduces broad cohort-level trajectories and is evaluated with leave-one-wave-out forecasting and comparisons against simple statistical baselines. A second longitudinal dataset of U.S. dental student data provides an external validation test, demonstrating that low-dimensional dynamics initialized from entropy measures can generalize across cohorts with different measurement instruments, demographic compositions, and timescales. Across both datasets, ECTO achieves stable out-of-sample performance, indicating that major cohort-level trends can be captured without assuming complex latent-variable models or time-varying causal inputs. Entropy here functions as a compact summary of population heterogeneity rather than a dynamical driver, and the coupled ODEs supply an interpretable alternative to high-dimensional or black box machine-learning approaches. This framework establishes a concise, transparent method for linking information-theoretic preprocessing with cohort-level dynamical modeling and provides a foundation for future multivariate or multi-cohort extensions.

## Full-text entities

- **Genes:** TRIM33 (tripartite motif containing 33) [NCBI Gene 51592] {aka DDH4, ECTO, PTC7, RFG7, TF1G, TIF1G}
- **Diseases:** anxiety (MESH:D001007), irritability (MESH:D001523), depression (MESH:D003866)
- **Chemicals:** PONE-D-25-39290R1 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC13001968/full.md

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Source: https://tomesphere.com/paper/PMC13001968