# Severe Varicella Pneumonia in an Immunocompetent Adult Requiring Intensive Care Management: A Case Report

**Authors:** Manal El Goubi, Mohmmed Moussaoui, Khalid K Khaleq

PMC · DOI: 10.7759/cureus.103763 · Cureus · 2026-02-17

## TL;DR

A healthy adult developed severe pneumonia from chickenpox and recovered after antiviral treatment.

## Contribution

Highlights the rare but severe risk of varicella pneumonia in immunocompetent adults.

## Key findings

- A 32-year-old immunocompetent adult developed severe varicella pneumonia requiring ICU care.
- Early antiviral treatment with acyclovir and valacyclovir led to clinical and radiological improvement.
- Chest CT showed bilateral ground-glass opacities consistent with viral pneumonia.

## Abstract

Varicella is usually a mild childhood disease; however, primary infection in adults may lead to severe complications, particularly varicella pneumonia. We report the case of a 32-year-old previously healthy male admitted to the intensive care unit with acute hypoxemic respiratory failure occurring three days after the onset of a diffuse vesicular rash. Chest CT demonstrated bilateral ground-glass opacities with focal consolidation consistent with viral pneumonia. The diagnosis was established based on typical cutaneous findings, epidemiological exposure, and compatible imaging results. Early treatment with intravenous acyclovir followed by oral valacyclovir resulted in favorable clinical and radiological outcomes. This case emphasizes the importance of early recognition and prompt antiviral therapy to improve prognosis, even in immunocompetent adults without classical risk factors.

## Linked entities

- **Chemicals:** acyclovir (PubChem CID 135398513), valacyclovir (PubChem CID 135398742)
- **Diseases:** Varicella (MONDO:0005700)

## Full-text entities

- **Diseases:** infection (MESH:D007239), vesicular rash (MESH:D005076), hypoxemic respiratory failure (MESH:D012131), Varicella (MESH:D002644)
- **Chemicals:** acyclovir (MESH:D000212), valacyclovir (MESH:D000077483)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13001835/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC13001835/full.md

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Source: https://tomesphere.com/paper/PMC13001835