# Safety of cardiopulmonary exercise testing in pulmonary hypertension: insights from a UK tertiary referral centre

**Authors:** Andrea Baccelli, Gulammehdi Haji, Hannah Tighe, Luke S. Howard

PMC · DOI: 10.1183/13993003.02207-2025 · The European Respiratory Journal · 2026-03-19

## TL;DR

This study shows that cardiopulmonary exercise testing is very safe for patients with pulmonary hypertension when done under proper supervision.

## Contribution

The study provides safety data from over 3800 tests, supporting the wider use of CPET in pulmonary hypertension.

## Key findings

- No deaths or syncopal events occurred during over 3800 CPET tests.
- The adverse event rate was only 0.05%.
- CPET is safe for patients with suspected or confirmed pulmonary hypertension.

## Abstract

Cardiopulmonary exercise testing (CPET) remains the gold standard for evaluating exercise capacity, offering a comprehensive assessment of the integrative metabolic, cardiovascular and ventilatory responses to exertion [1, 2].

Incremental, symptom-limited CPET is safe in patients with suspected or confirmed pulmonary hypertension. In over 3800 tests, no deaths or syncopal events occurred, with an adverse event rate of only 0.05%, supporting wider use under proper supervision.
https://bit.ly/4qdZf6x

## Linked entities

- **Diseases:** pulmonary hypertension (MONDO:0005149)

## Full-text entities

- **Diseases:** Pulmonary Hypertension (MESH:D006976)

## Full text

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC13000393/full.md

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Source: https://tomesphere.com/paper/PMC13000393