# Neonatal jaundice detection using a vision transformer-based deep learning model

**Authors:** Mehrnoush Lotfi, Mohammad Rabiee, Masoomeh Haghbin Nazarpak, Razieh Sangesari, Nazanin Alishahi, Mohammad Saber Azimi

PMC · DOI: 10.1038/s41598-026-40515-5 · 2026-02-16

## TL;DR

This paper presents a deep learning model using Vision Transformers for non-invasive detection of neonatal jaundice via smartphone images, offering a low-cost and accurate alternative to traditional methods.

## Contribution

The study introduces a Vision Transformer-based model for neonatal jaundice detection that outperforms existing methods in accuracy and generalizability.

## Key findings

- The T2T-ViT model achieved 99% performance across multiple metrics for neonatal jaundice detection.
- Transformer-based models outperformed convolutional and traditional machine learning models in this task.
- The approach is feasible for scalable, non-invasive screening in low-resource settings.

## Abstract

Neonatal jaundice is a prevalent and potentially serious condition that can lead to severe complications if undiagnosed or untreated. While traditional diagnostic methods like blood sampling are invasive and time-consuming, and transcutaneous bilirubinometers remain costly, smartphone-based image analysis offers a promising low-cost, non-invasive alternative. However, most existing solutions rely on traditional machine learning techniques with limited accuracy and generalizability. In this study, we introduce a deep learning approach based on the Vision Transformer (T2T-ViT) and compare its performance with three other models, ResNet, Support Vector Machine (SVM), and K-Nearest Neighbors (k-NN), using a clinically annotated dataset of neonatal skin images captured via a smartphone camera. The models were evaluated using multiple performance metrics including accuracy, precision, recall, F1-score, Matthews Correlation Coefficient (MCC), and Area under the Curve (AUC). The T2T-ViT model achieved 99% across all metrics, significantly outperforming both convolutional and traditional machine learning models. These findings demonstrate the feasibility of applying transformer-based deep learning architectures for accessible, scalable, and accurate non-invasive neonatal jaundice screening, potentially enabling early intervention in resource-limited settings. This approach could serve as an accessible, scalable screening tool for neonatal jaundice detection, particularly in low-resource clinical settings.

## Full-text entities

- **Diseases:** Neonatal jaundice (MESH:D007567)

## Figures

13 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13000152/full.md

---
Source: https://tomesphere.com/paper/PMC13000152