# Effect of minimally invasive non-surgical periodontal therapy in former smokers with periodontitis on salivary IL-1β and PGE-2 profile

## TL;DR

This study compares how different dental treatments and smoking cessation affect inflammation markers in saliva for people with gum disease.

## Contribution

The study introduces a comparison of minimally invasive versus conventional dental treatments and smoking cessation effects on salivary inflammatory markers in periodontitis patients.

## Key findings

- MINST significantly reduced salivary PGE2 and IL-1β levels in former smokers compared to continuing smokers.
- Non-smokers and SQ2 group showed similar significant reductions in inflammatory markers.
- MINST was more effective than conventional therapy in controlling inflammation in former smokers.

## Abstract

Limited data are available regarding salivary inflammatory marker levels following conventional versus minimally invasive non-surgical periodontal therapy and smoking cessation. This study aimed to evaluate the effects of conventional non-surgical periodontal therapy (CNST) versus minimally invasive non-surgical periodontal therapy (MINST) on the levels of salivary inflammatory markers, specifically interleukin-1β (IL-1β) and prostaglandin E2 (PGE2), in patients with stage III grade A/B periodontitis. Moreover, it investigated the impact of smoking cessation on these biomarkers and compared outcomes among smokers, non-smokers (NS), and individuals who quit smoking.

A randomized controlled biochemical trial was conducted with 40 patients divided into four groups: smokers who quit and received conventional therapy (SQ1), smokers who quit and received minimally invasive therapy (SQ2), smokers continuing to smoke (SC), and NS.

Both the SQ2 and NS groups reported significant reductions in salivary PGE2 and IL-1β levels at both observation periods compared with the SC group.

MINST appeared more effective in controlling inflammatory markers among patients who quit smoking compared with conventional non-surgical therapy.