# On the origins and variation of nucleotide skews of archaeal genomes

## TL;DR

This paper explores how nucleotide skews in archaeal genomes differ from bacterial ones, revealing unique evolutionary patterns in archaea.

## Contribution

The study introduces a computational approach to analyze nucleotide skews, highlighting archaea's reduced strand-specific mutation and DNA repair abilities.

## Key findings

- Translational selection and genetic code shape nucleotide skews in archaeal genomes.
- Archaea show reduced strand-specific mutation and DNA repair compared to bacteria.
- The approach can help study evolutionary dynamics of archaeal chromosomes.

## Abstract

We have used nucleotide skews as the proxy to understand the evolution of archaeal genomes. Our genome-wide studies using substantial datasets suggest that translational selection and the nature of the genetic code are universally conserved determinants of asymmetric guanine and cytosine distributions. We propose that in the case of the majority of bacterial chromosomes, mutational processes and/or DNA repair also result in the strand-specific nucleotide skews. This is in stark contrast to what we observe for archaeal chromosomes and plasmids, and reveals that archaea have a greatly reduced ability to create mutations and/or repair DNA damage in a strand-specific manner. We suggest that in the future, the described computational and statistical approach will help to understand the evolutionary dynamics of the archaeal chromosomes through the tree of life.