PID-controller enhanced artificial β-cells
Lin Liu, Bruna Jacobson, Darko Stefanovic
TL;DR
Researchers propose using a PID controller to improve artificial β-cells for better glucose regulation in diabetic mice.
Contribution
The novel contribution is the integration of a PID controller into artificial β-cells to enhance glucose regulation.
Findings
PID-controlled artificial β-cells can shut down insulin production in time and maintain proper glycemia levels.
The enhanced models outperform non-PID-controlled cells in regulating glucose in Type 1 diabetic mice.
The design adds more tuning space to the high-dimensional dynamic system of artificial β-cells.
Abstract
Conventional management of diabetes via injection or external insulin pumps suffers from inconvenience and inability to accurately maintain blood glucose levels. A potential solution to these problems consists of implanting synthetic artificial β-cells that can sense glucose and transcribe insulin protein. Experimental results from Xie et al. show these cells are able to release insulin and somewhat improve postprandial glucose levels in diabetic mice. However, they fail to achieve the degree of glucose regulation as in healthy mice. In our analysis, we explain that this artificial β-cell system has a major disadvantage: it is a high-dimensional dynamic system but with little tuning space. Here, we propose an analytical model of a PID-controller-based enhanced artificial β-cell design to solve this issue. Our numerical simulations show that a model of PID-controlled engineered…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34
Figure 35
Figure 36
Figure 37
Figure 38
Figure 39
Figure 40
Figure 41
Figure 42
Figure 43
Figure 44
Figure 45
Figure 46
Figure 47
Figure 48
Figure 49
Figure 50Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsPancreatic function and diabetes · Diabetes Management and Research · Hyperglycemia and glycemic control in critically ill and hospitalized patients