# Recurrent Symptomatic Hyponatremia Revealing a Late Diagnosis of Sheehan Syndrome and Effectively Treated With Levothyroxine: A Case Report and Brief Review of Literature

**Authors:** Hayatu Awel Abdela, Germen Temam Abdulmalik, Numeri Husein Kimo, Kumel Nur Muktar, Rebi Ali Oumer, Tamirat Godebo Woyimo

PMC · DOI: 10.1002/ccr3.71285 · 2025-10-15

## TL;DR

A woman with a history of postpartum hemorrhage was diagnosed with Sheehan syndrome after experiencing chronic symptoms, and her condition improved with levothyroxine treatment.

## Contribution

This case highlights the importance of considering Sheehan syndrome in women with postpartum hemorrhage and chronic symptoms.

## Key findings

- Recurrent hyponatremia led to the late diagnosis of Sheehan syndrome in a postpartum woman.
- Levothyroxine treatment effectively managed the symptoms of the patient.
- Early hormonal replacement therapy is crucial for reversing complications and improving quality of life.

## Abstract

In women with a history of postpartum hemorrhage presenting with chronic symptoms such as hyponatremia, amenorrhea, weight loss, or cold intolerance, suspect Sheehan's syndrome. Early diagnosis and prompt hormonal replacement therapy are essential for reversing complications and improving quality of life. Prioritize evaluation of pituitary function in these patients to ensure timely intervention.

## Linked entities

- **Chemicals:** levothyroxine (PubChem CID 5819)
- **Diseases:** Sheehan syndrome (MONDO:0019618)

## Full-text entities

- **Diseases:** weight loss (MESH:D015431), Hyponatremia (MESH:D007010), Sheehan Syndrome (MESH:D007018), postpartum hemorrhage (MESH:D006473)
- **Chemicals:** Levothyroxine (MESH:D013974)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12998242/full.md

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Source: https://tomesphere.com/paper/PMC12998242