# Tear and blood salusin-α, and -β, copeptin, and asprosin in patients with glaucoma and ocular hypertension

## TL;DR

This study found that certain biomarkers in blood and tears differ in patients with glaucoma and ocular hypertension compared to healthy individuals.

## Contribution

The study is the first to measure salusin-α, salusin-β, copeptin, and asprosin levels in tears and blood of glaucoma and ocular hypertension patients.

## Key findings

- Patients with glaucoma and ocular hypertension had significantly lower salusin-α and salusin-β levels in blood and tears.
- Copeptin and asprosin levels were significantly higher in these patient groups compared to controls.
- Salusin levels negatively correlated with intraocular pressure.

## Abstract

This pilot study was conducted to investigate the presence of various
bioactive compounds (copeptin, asprosin, and salusins) in the blood and
tears of patients with glaucoma.

A total of 83 subjects, including 28 patients with open-angle glaucoma, 28
patients with ocular hypertension, and 27 control volunteers, were enrolled
in this study. The levels of salusin-α, salusin-β, copeptin,
and asprosin in tears and venous blood samples were measured by enzyme
linked immunosorbent assay (ELISA).

Patients with open-angle glaucoma and those with ocular hypertension showed
statistically significantly decreased levels of salusin-α and
salusin-β in their blood and tears compared with those of control
subjects (p<0.05), with the decrease being the most pronounced in
patients with ocular hypertension (p<0.05). In contrast, the levels of
copeptin and asprosin showed a statistically significant increase in both
these patient groups compared with those of control subjects (p<0.05).
There was a negative correlation between intraocular pressure and blood and
tear salusins.

Fluids from patients with open-angle glaucoma and ocular hypertension showed
lower salusin levels. Patients with ocular hypertension had higher levels of
copeptin and asprosin, but not those with open-angle glaucoma (except for
asprosin, whose levels showed a slight but remarkable increase in plasma in
patients with open-angle glaucoma). The pathogenesis of ocular hypertension
and open-angle glaucoma may be significantly impacted by these
biomarkers.