# Miniaturisation of Raman spectroscopy systems: from benchtop to backpocket

**Authors:** Mike Hardy, Pooja P. Kanade, Emma Buchan, Pola Goldberg Oppenheimer, Cillian P. T. McPolin, Robert M. Bowman

PMC · DOI: 10.1039/d5lc00836k · Lab on a Chip · 2026-03-18

## TL;DR

This paper discusses how Raman spectroscopy systems are becoming smaller, from large lab equipment to pocket-sized devices, enabling new applications in consumer and field settings.

## Contribution

The paper provides a comprehensive analysis of the miniaturisation trends and future prospects of Raman spectroscopy systems.

## Key findings

- Handheld Raman systems have gained popularity since 2010 across various applications.
- Fully integrated on-chip Raman devices could be used in consumer goods and drones.
- Plasmon-enhanced Raman technologies enable ultra-low detection levels.

## Abstract

The global portable spectroscopy market is rapidly expanding, with optical technologies composing the greatest market share. One prominent light-based technology is Raman spectroscopy, which confers benefits in terms of high selectivity and thus untargeted detection and multiplexing capabilities. Alongside this, plasmon-enhanced Raman technologies can provide ultra-low, even single molecule, detection. In this article, we analyse the current trends in the miniaturisation of Raman systems, including constituent components, evaluating current market needs, and providing a prospective on likely developments within Raman spectroscopy systems in the coming years. In particular, the progress from handheld Raman systems, which have surged in popularity since 2010 in a plethora of application spaces, to fully integrated on-chip Raman devices, is surveyed. Such palm-sized devices offer potentially easy integration into, for example, consumer white goods at home, and lightweight drone systems, and thus could transform the portable sensing landscape.

‘Progress of Raman systems from open-bench systems to miniaturised systems.’ Image generated with the assistance of Google Gemini.

## Full-text entities

- **Diseases:** Alzheimer's (MESH:D000544), cervical cancers (MESH:D002583), astigmatism (MESH:D001251), brain cancer (MESH:D001932), breast cancer (MESH:D001943), PoC (MESH:D003428), pains (MESH:D010146), skin diseases (MESH:D012871), tremor (MESH:D014202), COVID-19 (MESH:D000086382), coma (MESH:D003128), TBI (MESH:D000070642), cancer (MESH:D009369), kidney disease (MESH:D007674), atopic dermatitis (MESH:D003876), DCSI (MESH:D002285)
- **Chemicals:** CO2 (MESH:D002245), Metals (MESH:D008670), platinum (MESH:D010984), PP (MESH:D011126), InP (MESH:C090882), N-acetylaspartate (MESH:C000179), alcohol (MESH:D000438), AgNO3 (MESH:D012835), boron (MESH:D001895), gold (MESH:D006046), essential oil (MESH:D009822), p-coumaric acid (MESH:C495469), isopropyl alcohol (MESH:D019840), aluminium (MESH:D000535), SiO2 (MESH:D012822), silver (MESH:D012834), acrylonitrile (MESH:D000181), aluminium oxide (MESH:D000537), water (MESH:D014867), creatine (MESH:D003401), polymer (MESH:D011108), PMMA (MESH:D019904), (fluorine (MESH:D005461), uric acid (MESH:D014527), styrene (MESH:D020058), 2-flurormethamphetamine (-), PTFE (MESH:D011138), ethylene carbonate (MESH:C031133), epoxy (MESH:D004853), diamond (MESH:D018130), polyurethane (MESH:D011140), methane (MESH:D008697), hydrogen (MESH:D006859), Si3N4 (MESH:C032734), butadiene (MESH:C031763), Si (MESH:D012825), barium titanate (MESH:C024547), quartz (MESH:D011791), GaAs (MESH:C043055), ethanol (MESH:D000431), polystyrene (MESH:D011137), sarin (MESH:D012524), oil (MESH:D009821), mercury (MESH:D008628), carbon (MESH:D002244)
- **Species:** Escherichia coli (E. coli, species) [taxon 562], Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12997533/full.md

## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12997533/full.md

## References

225 references — full list in the complete paper: https://tomesphere.com/paper/PMC12997533/full.md

---
Source: https://tomesphere.com/paper/PMC12997533