# Engineering PRRs: A new path to durable resistance

**Authors:** Dongjiao Wang, Zhankun Li, Wentao Yang, Youxiong Que, Ming Chang

PMC · DOI: 10.1016/j.abiote.2026.100028 · aBIOTECH · 2026-02-12

## TL;DR

Scientists engineered a plant receptor to boost immunity against diseases without affecting plant growth.

## Contribution

A reprogrammed immune receptor provides broad-spectrum disease resistance across species.

## Key findings

- Structural optimization of RLP23 enables functional signaling triggered by nlp20.
- The engineered receptor confers broad-spectrum disease resistance without growth compromise.
- Rationally reprogrammed receptors offer a durable strategy for crop protection.

## Abstract

Engineering the Arabidopsis cell-surface immune receptor RECEPTOR-LIKE PROTEIN 23 (RLP23) enhances plant immunity by enabling functional signaling triggered by the conserved pathogen peptide nlp20. Structural optimization enables broad-spectrum disease resistance across species without compromising growth, demonstrating the potential of rationally reprogrammed pattern recognition receptors as a durable and sustainable strategy for crop protection.

## Linked entities

- **Genes:** RLP23 (receptor like protein 23) [NCBI Gene 817828], RLP23 (receptor like protein 23) [NCBI Gene 817828]
- **Species:** Arabidopsis (taxon 3701)

## Full-text entities

- **Genes:** RLP23 (receptor like protein 23) [NCBI Gene 817828] {aka AtRLP23, F24L7.18, F24L7_18, receptor like protein 23}
- **Chemicals:** nlp20 (-)
- **Species:** Arabidopsis thaliana (mouse-ear cress, species) [taxon 3702]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12997209/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12997209/full.md

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Source: https://tomesphere.com/paper/PMC12997209