# Intraoperative sodium range affects white matter microstructure in neonatal congenital heart disease

## TL;DR

Rapid changes in sodium levels during surgery in newborns with heart defects may harm white matter in the brain, suggesting the need to carefully manage sodium levels to protect brain development.

## Contribution

This study is the first to show that intraoperative sodium fluctuations are linked to neonatal white matter microstructural changes after heart surgery.

## Key findings

- A larger intraoperative sodium range was associated with reduced axial diffusivity in specific white matter regions.
- No associations were found between diffusivity and sodium rate of change.
- Findings suggest axonal injury may result from rapid sodium fluctuations in neonates with congenital heart disease.

## Abstract

Intraoperative sodium changes and new postoperative white matter injury are prevalent in neonates with congenital heart disease (CHD) who undergo cardiopulmonary bypass surgery. Rapid sodium correction in hyponatremia is associated with white matter injury in adults. This study examined the potential effects of a rapid intraoperative sodium increase on white matter microstructure in neonates with CHD.

83 neonates with CHD underwent postoperative diffusion weighted magnetic resonance imaging within three weeks of cardiopulmonary bypass surgery as part of routine clinical practice. Mean diffusivity, radial diffusivity, and axial diffusivity were calculated using Diffusion Tensor Imaging. Voxel-wise associations within the core of white matter tracts were assessed using tract-based spatial statistics. Serum sodium measurements were extracted from clinical notes. Maximum intraoperative sodium range was defined as the difference between the minimum and maximum serum sodium observations during surgery. The rate of sodium change was calculated as this range divided by the time interval in hours.

A larger maximum intraoperative sodium range was associated with lower axial diffusivity values in the right centrum semiovale, bilateral precentral white matter, right inferior longitudinal fasciculus, and right optic radiation (p < 0.05, family wise error rate corrected). There were no other associations between diffusivities and sodium range or rate of change.

A larger maximum intraoperative sodium range was associated with reduced axial diffusivity, possibly indicating axonal injury in neonates with CHD after cardiopulmonary bypass surgery. These findings underscore the importance of limiting perioperative osmotic stress to optimize white matter microstructural development.

•White matter injury is common after neonatal congenital heart disease surgery.•A rapid correction of low sodium is associated with white matter injury in adults.•Intraoperative serum sodium range affects white matter microstructural development.•Perioperative osmotic stress should be limited to optimize white matter development.

White matter injury is common after neonatal congenital heart disease surgery.

A rapid correction of low sodium is associated with white matter injury in adults.

Intraoperative serum sodium range affects white matter microstructural development.

Perioperative osmotic stress should be limited to optimize white matter development.