# Copper catalyzed synthesis of thiazole derivatives from enaminones, amines and CS₂

## TL;DR

A new copper-catalyzed method efficiently produces thiazole compounds using enaminones, amines, and carbon disulfide under simple conditions.

## Contribution

A novel, ligand-free copper-catalyzed synthesis of thiazoles using CS₂ as a dual carbon and sulfur source.

## Key findings

- The method achieves good to excellent yields of thiazole derivatives under mild conditions.
- Carbon disulfide functions as both a sulfur and carbon source in the reaction.
- The approach is tolerant to various functional groups and produces biologically relevant scaffolds.

## Abstract

An efficient copper-catalyzed method for the synthesis of thiazoles from enaminones, amines, and carbon disulfide (CS₂) is described. This one-pot, ligand- and additive-free protocol proceeds under relatively simple reaction conditions, affording thiazole derivatives in good to excellent yields. Notably, CS₂ serves as a combined sulfur and carbon source, contributing to the synthetic practicality of the transformation. The method demonstrates good functional-group tolerance and provides a straightforward approach to biologically relevant thiazole scaffolds.

The online version contains supplementary material available at 10.1038/s41598-026-40393-x.