# Advancements in microalgae-mediated technologies for antibiotic removal from wastewater: a review

**Authors:** Neha Pathania, Swati Kumari, Kamlesh Thakur, Saurabh Kulshrestha, Rohit Khargotra

PMC · DOI: 10.1007/s10532-026-10273-2 · Biodegradation · 2026-03-17

## TL;DR

This paper reviews how microalgae can be used to remove antibiotics from wastewater, offering a promising alternative to traditional methods.

## Contribution

The paper provides a comprehensive review of microalgae-based technologies for antibiotic removal, highlighting their mechanisms and integration with other methods.

## Key findings

- Microalgae can remove antibiotics through adsorption, accumulation, and biodegradation.
- Factors like pH, temperature, and light intensity significantly affect antibiotic removal efficiency.
- Combining microalgae with technologies like photocatalysis enhances wastewater treatment.

## Abstract

The development of efficient systems for removing antibiotics from wastewater is being pushed by increase in antibiotic resistance brought on by the environmental discharge of antibiotics. Antibiotic were not completely eliminated using conventional technologies like activated sludge, constructed wetland systems and many other procedures. A viable alternative for treating wastewater through adsorption, accumulation, biodegradation, photodegradation, and hydrolysis has recently been investigated using microalgae-based technology. This review focuses on effects of antibiotics on microalgae, as well as the ways in which microalgae remove antibiotics and how they work with other technologies to do so, including photocatalysis, advanced oxidation, and complementary microorganism degradation. The physiochemical and operational parameters like pH, temperature, light intensity and many more which influence the elimination of antibiotics in the wastewater treatment system. Future research requirements, further opportunities, the limitations of the available microalgae-based technologies were also discussed.

## Linked entities

- **Chemicals:** antibiotics (PubChem CID 46874763)

## Full-text entities

- **Diseases:** infectious (MESH:D003141), Toxicity (MESH:D064420), water-borne illnesses (MESH:D016751)
- **Chemicals:** kanamycin (MESH:D007612), TC (MESH:D013667), Vitamin B12 (MESH:D014805), cefazolin (MESH:D002437), graphene oxide (MESH:C000628730), CO2 (MESH:D002245), Tetracycline (MESH:D013752), phosphorus (MESH:D010758), Water (MESH:D014867), chlorophyll (MESH:D002734), NaCl (MESH:D012965), nitrogen (MESH:D009584), Levofloxacin (MESH:D064704), metronidazole (MESH:D008795), ciprofloxacin (MESH:D002939), ester (MESH:D004952), clarithromycin (MESH:D017291), cephalosporin (MESH:D002511), ROS (MESH:D017382), hydroxyl radicals (MESH:D017665), doxycycline (MESH:D004318), Erythromycin (MESH:D004917), sulfonamides (MESH:D013449), Fluoroquinolones (MESH:D024841), OFL (MESH:D015242), biochar (MESH:C540010), H2O2 (MESH:D006861), penicillin (MESH:D010406), SMX (MESH:D013420), OH (MESH:C031356), methylparaben (MESH:C015358), CTC (MESH:C072046), glutathione (MESH:D005978), Sulphaguanidine (MESH:D013414), AMP (MESH:D000667), chlorine (MESH:D002713), TiO2 (MESH:C009495), trimethoprim (MESH:D014295), quinolones (MESH:D015363), ceftazidime (MESH:D002442), SMZ (MESH:D013418), cephapirin (MESH:D002514), beta-lactam (MESH:D047090), free radical (MESH:D005609), SDZ (MESH:D013411), EPS (MESH:C100219), SM (MESH:D012493), NFX (MESH:D009643), cefradine (MESH:D002515), Auxenochlorellaprotothecoides (-), cephalexin (MESH:D002506), polymer (MESH:D011108), carbon (MESH:D002244), VOCs (MESH:D055549), RTM (MESH:D015575), tetracyclines (MESH:D013754), ozone (MESH:D010126), chlorophyll B (MESH:C037184), O2 (MESH:D010100), heavy metal (MESH:D019216)
- **Species:** Chlorella vulgaris (species) [taxon 3077], Chlorophyta (green algae, phylum) [taxon 3041], PX clade (clade) [taxon 569578], activated sludge metagenome (species) [taxon 942017], Tetradesmus obliquus (species) [taxon 3088], Chlamydomonas acidophila (species) [taxon 257625], Auxenochlorella protothecoides (species) [taxon 3075], Homo sapiens (human, species) [taxon 9606], Nannochloris sp. (species) [taxon 2339217], Mucidosphaerium pulchellum (species) [taxon 247497], Chlorella sorokiniana (species) [taxon 3076], Bos taurus (bovine, species) [taxon 9913], Raphidocelis subcapitata (species) [taxon 307507], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Chlorella sp. (species) [taxon 3079], Chlamydomonas reinhardtii (species) [taxon 3055]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12996005/full.md

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Source: https://tomesphere.com/paper/PMC12996005