# One‐Pot Transition‐Metal‐Free Methods for the Synthesis of All Three Bonds of the Alkyne's Triple Bond

## TL;DR

This paper reviews efficient, transition-metal-free methods to synthesize all three bonds of an alkyne's triple bond in a single step.

## Contribution

The novelty lies in compiling and analyzing one-pot, transition-metal-free methods for alkyne synthesis.

## Key findings

- One-pot methods can form all three bonds of alkynes without transition metals.
- Proposed mechanisms and evaluations of strengths and weaknesses are provided for each method.
- The review assesses the scalability and industrial applicability of current alkyne synthesis methods.

## Abstract

Alkynes are among the most useful functional groups in synthetic chemistry, as they are excellent starting materials for various reactions and serve as valuable precursors during total synthesis. Despite the high number of transformations that utilize alkynes as substrates, few methods actually exist to synthesize them. Known methods involve several synthetic steps, harsh conditions, or cryogenic temperatures, which render them inconvenient and inefficient. This review of alkyne syntheses cover methods that enable the formation of all three bonds of the alkyne's triple bond in a transition‐metal‐free, one‐pot fashion. This review offers a guide to gauge if current methods are potentially suitable to be scaled and used in industry and pharmaceutical processes.

One‐pot transition‐metal‐free methods for the synthesis of all three bonds of the alkyne's triple bond are reviewed. After analysis of several named reactions and discussion of improvements, recent advances in the synthesis of alkynes are discussed. Each section contains a proposed reaction mechanism and analysis of the strengths and weaknesses of the approaches.