# Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer after prior vascular endothelial growth factor receptor-targeted therapy (COSMIC-311): outcomes by BRAF status

## TL;DR

This study shows that cabozantinib improves survival and response rates in thyroid cancer patients, regardless of a specific genetic mutation.

## Contribution

The study provides evidence that cabozantinib is effective in radioiodine-refractory thyroid cancer patients with or without the BRAFV600E mutation.

## Key findings

- Cabozantinib improved progression-free survival in both BRAF wild-type and BRAFV600E subgroups.
- Objective response rates were observed with cabozantinib but not with placebo in both subgroups.
- Adverse events were more common with cabozantinib but manageable.

## Abstract

Cabozantinib is approved for previously treated radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) based on improved progression-free survival (PFS) versus placebo in the COSMIC-311 study. The BRAFV600E mutation is common in DTC and is associated with poor prognosis. This planned exploratory analysis of COSMIC-311 reports outcomes by BRAF status.

In this exploratory analysis, outcomes by BRAFwt (wild-type) or BRAFV600E status were evaluated in the COSMIC-311 phase 3 study in patients with RAIR-DTC who had previously received lenvatinib and/or sorafenib.

BRAF status was available for 106 of 258 patients enrolled in COSMIC-311; of these, 74 had BRAFwt and 27 had BRAFV600E. Cabozantinib prolonged PFS versus placebo in both the BRAFwt (hazard ratio [HR] 0.23 [95% CI: 0.12–0.44]; median PFS, 11.1 versus 1.9 months) and BRAFV600E (HR 0.15 [95% CI: 0.04–0.59]; median PFS, 9.2 versus 1.9 months) subgroups. While no responses were observed with placebo in both BRAF subgroups, objective response rates (ORRs) of 11% and 18% were observed with cabozantinib in the BRAFwt and BRAFV600Esubgroups, respectively. Among patients treated with cabozantinib, 68% of the BRAFwt group and 53% of the BRAFV600E group reported grade 3/4 treatment-emergent adverse events; the incidences were 17% and 50% in the corresponding groups treated with placebo.

In this subgroup analysis of COSMIC-311, cabozantinib improved PFS and ORR versus placebo irrespective of BRAF mutation status. Thus, cabozantinib is an efficacious treatment option with a manageable safety profile for previously treated patients with RAIR-DTC, including those with BRAFV600E.