# Noncommunicable chronic diseases and health challenges in 2050

**Authors:** Deborah Carvalho Malta, Guilherme Augusto Veloso, Crizian Saar Gomes, Maurício Lima Barreto, Deborah Carvalho Malta, Guilherme Augusto Veloso, Crizian Saar Gomes, Maurício Lima Barreto

PMC · DOI: 10.1590/1980-549720260011 · Revista Brasileira de Epidemiologia (Brazilian Journal of Epidemiology) · 2026-03-16

## TL;DR

This study projects that noncommunicable diseases will shift in focus by 2050, with cancer overtaking heart disease as the top cause of death.

## Contribution

The study provides new projections of NCD trends and risk factors in Brazil up to 2050, highlighting policy implications.

## Key findings

- Premature NCD mortality in Brazil dropped by 37.7% from 1990 to 2021.
- Cardiovascular disease is projected to be overtaken by cancer as the leading cause of death by 2050.
- Rising risk factors like obesity and poor diet may hinder global NCD reduction targets.

## Abstract

The study aims to analyze the burden of diseases related to noncommunicable chronic diseases (NCDs) and their risk factors (RFs) from 1990 to 2021 and to project of NCDs and RFs for the years 2030 and 2050.

Estimates of risk factors and mortality from NCDs in Brazil and its States were analyzed based on data from the Global Burden of Disease Study.

There was a 37.7% reduction in premature mortality rates from NCDs and a 34% reduction in Disability-Adjusted Life Years (DALYs) between 1990 and 2021. Projections for 2050 indicate that mortality from cardiovascular diseases will continue to decline and that these will be supplanted by neoplasms. Mortality rates from diabetes tend to increase, while chronic respiratory diseases show a downward trend. In 2021, the main risk factors associated with premature deaths from NCDs were: high blood pressure, smoking, poor diet, high Body Mass Index (BMI), and high fasting glucose. Projections through 2050 point to an increase in risk factors such as obesity, high blood pressure, high glucose, physical inactivity, and poor diet - which may compromise the achievement of the 2050 targets for reducing premature mortality from NCDs.

The study points out that global targets may not be achieved, raising an alert to the urgent need to strengthen public policies aimed at the prevention and control of NCDs.

O estudo visa analisar a carga de doenças relacionadas às Doenças Crônicas não Transmissíveis (DCNT) e aos seus Fatores de Risco (FR) no período de 1990 a 2021; e projetar a evolução de DCNT e FR para os anos de 2030 e 2050.

Foram analisadas estimativas de fatores de risco e de mortalidade por DCNT no Brasil e em suas unidades da federação, com base nos dados do Estudo Global de Doenças.

Observou-se uma redução de 37,7% nas taxas de mortalidade prematura por DCNT e de 34% em Anos de Vida Ajustados por Incapacidade (DALYs) entre 1990 e 2021. As projeções para 2050 indicam que a mortalidade por doenças cardiovasculares continuará em queda, e que estas serão suplantadas pelas neoplasias. As taxas de mortalidade por diabetes tendem a aumentar, enquanto as doenças respiratórias crônicas apresentam tendência de redução. Em 2021, os principais FR associados às mortes prematuras por DCNT foram: pressão arterial elevada, tabagismo, alimentação inadequada, Índice de Massa Corporal (IMC) elevado e glicose em jejum elevada. As projeções até 2050 apontam aumento nos fatores de risco obesidade, pressão arterial elevada, glicose elevada, inatividade física e dieta inadequada - o que pode comprometer o alcance das metas de redução da mortalidade prematura por DCNT estabelecidas para 2050.

O estudo aponta que as metas globais podem não ser alcançadas, acendendo um alerta para a necessidade urgente de fortalecimento das políticas públicas voltadas à prevenção e ao controle das DCNT.

## Linked entities

- **Diseases:** diabetes (MONDO:0005015)

## Full-text entities

- **Diseases:** cardiovascular diseases (MESH:D002318), diabetes (MESH:D003920), obesity (MESH:D009765), respiratory diseases (MESH:D012140), NCDs (MESH:D000073296), chronic (MESH:D002908), neoplasms (MESH:D009369)
- **Chemicals:** glucose (MESH:D005947)

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12995342/full.md

## References

48 references — full list in the complete paper: https://tomesphere.com/paper/PMC12995342/full.md

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Source: https://tomesphere.com/paper/PMC12995342