# Identification of a novel HLA-G allele, HLA-G*01:66, using PolyseqOne and oxford nanopore sequencing

**Authors:** Ran Li, Liyan Sun, Siqi Cai

PMC · DOI: 10.3389/fgene.2026.1786514 · Frontiers in Genetics · 2026-03-04

## TL;DR

Researchers discovered a new HLA-G allele, HLA-G*01:66, using advanced sequencing techniques.

## Contribution

The paper introduces the novel HLA-G*01:66 allele identified through PolyseqOne and Oxford Nanopore sequencing.

## Key findings

- HLA-G*01:66 has a missense nucleotide substitution at position 508 in exon 3.
- The new allele was identified using PolyseqOne and Oxford Nanopore sequencing technologies.

## Abstract

HLA-G*01:66 differs from HLA-G*01:01:22:01 by one missense nucleotide substitution at position 508 in exon 3.

## Linked entities

- **Genes:** HLA-G (major histocompatibility complex, class I, G) [NCBI Gene 3135]

## Full-text entities

- **Genes:** HLA-G (major histocompatibility complex, class I, G) [NCBI Gene 3135] {aka MHC-G}

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12995184/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12995184/full.md

## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12995184/full.md

---
Source: https://tomesphere.com/paper/PMC12995184