# Persistent prostaglandin E2 upregulation and hormonal multi-resistance: A hypothesis for long COVID

## TL;DR

The paper suggests that long-term high levels of PGE2, a key inflammation mediator, may explain the wide range of symptoms in long COVID.

## Contribution

The paper proposes a novel hypothesis linking persistent PGE2 upregulation and imbalanced EP receptor signaling to long COVID.

## Key findings

- PGE2 elevation may disrupt homeostasis and lead to hormonal resistance in long COVID.
- PGE2 overactivity through EP receptors aligns with the diverse symptoms of long COVID.
- Persistent PGE2 dominance could create a self-sustaining cycle of inflammation and resistance.

## Abstract

An explanation for long COVID (LC) and its many symptoms remains elusive, and no unifying upstream mediator of its pathophysiology has yet been identified. Viral infections, including COVID-19, upregulate Prostaglandin E2 (PGE2), - the principal lipid mediator of inflammation. PGE2 has broad paracrine effects, including modulation of autoantibodies, nervous systems, blood pressure, glucose levels, and apoptosis. Upregulated, PGE2 may drive multiple pathological processes through its four receptors: EP1-EP4. Through EP3, PGE2 stimulates characteristic viral sickness symptoms. Both severe and mild disease may precede LC, possibly reflecting either excessive or insufficient EP3 activity, which we term “EP3 up” and “EP3 down”, respectively. In individuals with “EP3 up” or “EP3 down” states, elevated PGE2 levels may disrupt homeostasis. Diverse physical and mental stressors upregulate PGE2. Data suggest that multiple hormones and agents stimulate PGE2 production, while PGE2 reportedly antagonizes these agents, possibly functioning as a homeostatic limiter. Sufficiently elevated PGE2, “PGE2 dominance”, may interfere with their activity through inhibiting their release, overlapping subcellular signaling pathways or by stimulating phosphorylation and autoantibodies. Homeostatic elevations of PGE2-stimulating hormones, together with other PGE2-raising factors, may promote resistance to these hormones, resulting in persistent PGE2 upregulation. Literature suggests that PGE2 overactivity, mediated by imbalanced EP receptor signaling, aligns with the diverse symptomatology of LC. Based on our literature analysis, we propose that persistent upregulation of PGE2 plays a pivotal role in the development of LC. Consequently, validation of elements of this framework may help guide exploration of therapeutic strategies targeting PGE2 pathways or EP receptor regulation.

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•Persistent Prostaglandin E2 (PGE2) elevation may explain long COVID symptomatology.•PGE2, the principal lipid mediator of inflammation, is raised by viral infections.•PGE2 stimulates autoantibodies to receptors, possibly hindering ligand binding.•PGE2 reportedly antagonizes hormones and agents that stimulate PGE2 production.•"PGE2-dominance" could cause resistances that fuel its persistent upregulation.

Persistent Prostaglandin E2 (PGE2) elevation may explain long COVID symptomatology.

PGE2, the principal lipid mediator of inflammation, is raised by viral infections.

PGE2 stimulates autoantibodies to receptors, possibly hindering ligand binding.

PGE2 reportedly antagonizes hormones and agents that stimulate PGE2 production.

"PGE2-dominance" could cause resistances that fuel its persistent upregulation.