# AntibioticDB: An Updated and Improved Open-Access Database for the Antibacterial Research and Development Community

## TL;DR

AntibioticDB is an open-access database that has been updated and expanded to better support research into new antibacterial treatments.

## Contribution

The new release introduces expanded entries, improved chemical data integration, and enhanced search functionality.

## Key findings

- The database now contains over 3,500 entries, including a significant increase in historical natural product antibiotics.
- Integration with the IUPHAR/BPS Guide to Pharmacology and inclusion of chemical identifiers improve usability and data accuracy.
- Ongoing curation ensures the database remains the most comprehensive global resource for antibacterial agents.

## Abstract

AntibioticDB (https://www.antibioticdb.com/), originally established in 2017
and since 2021 led by the Global
Antibiotic Research & Development Partnership (GARDP), is a freely
available database of antibacterial agents to facilitate research
and development of new antibacterial therapeutics. Here, we describe
a new release of AntibioticDB that has been significantly expanded
and updated with the aid of user feedback and which offers additional
functionality through a redesigned web portal. Improvements include
reciprocal integration with the IUPHAR/BPS Guide to Pharmacology (https://www.guidetopharmacology.org), capturing of compound structure information in the form of standard
chemical identifiers (canonical and isomeric SMILES, InChI, and InChI
Key), chemical 2D structure images, and harmonizing terminology to
optimize database searching. Ongoing curation efforts have increased
the number of individual entries to >3,500, a process driven mostly
by a significant expansion of historical natural product antibiotics
that were previously under-represented in the database. The database
is continuously updated by mining the published literature and capturing
newly discovered antibacterial compounds as they are reported, making
AntibioticDB the most complete global resource on antibacterial agents.