# Chemical Profiling and Biological Activity of Copaiba Oil‐Resin Samples and Development of HPLC‐DAD Method for the Analysis of β‐Caryophyllene **Authors:** Gabriel de A. P. Graça, Cláudia G. Silva, Denise de O. Scoaris, Juliana Rodrigues de Vasconcelos, André Santos Alkimim, Vanessa C. F. Mosqueira, Luciana S. Salomon, Pietra Piotto Marcellini, Isabelle Renata Martins da Silva, Janete S. C. Santos, Andreia Fonseca Silva, Carolina P. S. Moreira, Júlio C. D. Lopes, Vera L. de Almeida PMC · DOI: 10.1002/bmc.70416 · Biomedical Chromatography · 2026-03-17 ## Full-text entities - **Genes:** Txnl4b (thioredoxin-like 4B) [NCBI Gene 234723] {aka D530025J19Rik, DLP, Dim2}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, TLR2 (toll like receptor 2) [NCBI Gene 7097] {aka CD282, TIL4}, Ms6hm (minisatellite 6 hypermutable) [NCBI Gene 17653] {aka PC-1}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, Ms6hm3 (minisatellite 6 hypermutable 3) [NCBI Gene 111469] {aka PC-2}, KCNH2 (potassium voltage-gated channel subfamily H member 2) [NCBI Gene 3757] {aka ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1}, CXCL1 (C-X-C motif chemokine ligand 1) [NCBI Gene 2919] {aka FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, Txnl4a (thioredoxin-like 4A) [NCBI Gene 27366] {aka D18Wsu98e, Dim1, Txnl4, U5-15kD, U5-15kDa}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta} - **Diseases:** eye irritation (MESH:D005128), infections (MESH:D007239), eye corrosion (MESH:D005134), S. capitis (MESH:D014006), DILI (MESH:D056486), Multiple Myeloma (MESH:D009101), inflammation (MESH:D007249), S. epidermitis (MESH:D004814), skin sensitization (MESH:D012871), carcinogenicity (MESH:D011230), ototoxicity (MESH:D006311), ocular irritation (MESH:D001523), MRSA (MESH:D013203), respiratory toxicity (MESH:D012140), neurotoxic (MESH:D020258), acute toxicity (MESH:D000208), non-small cell lung cancer (MESH:D002289), drug (MESH:D000081015), Cytotoxicity (MESH:D064420) - **Chemicals:** Chloramphenicol (MESH:D002701), OS (MESH:D009992), alkane (MESH:D000473), 2,3,5-triphenyltetrazolium chloride (MESH:C009591), copalic acid (MESH:C556511), ethyl acetate (MESH:C007650), ethanol (MESH:D000431), DMSO (MESH:D004121), terpene (MESH:D013729), oil (MESH:D009821), carbons (MESH:D002244), anisaldehyde (MESH:C024896), methicillin (MESH:D008712), CO4 (-), ester (MESH:D004952), diterpene (MESH:D004224), caryophyllene oxide (MESH:C515179), acetonitrile (MESH:C032159), CA (MESH:D002118), NaOH (MESH:D012972), formic acid (MESH:C030544), resazurin (MESH:C005843), sulphuric acid (MESH:C033158), hydrocarbon (MESH:D006838), resin (MESH:D012116), nitrogen (MESH:D009584), alpha-copaene (MESH:C000599751), mineral (MESH:D008903), saline (MESH:D012965), Hexane (MESH:D006586), lipoteichoic acid (MESH:C009900), alkene (MESH:D000475), ethyl ether (MESH:D004986), alpha-bergamotene (MESH:C423904), essential oil (MESH:D009822), water (MESH:D014867), aluminium (MESH:D000535), isopropanol (MESH:D019840), KOH (MESH:C029943), NaHCO3 (MESH:D017693), CO2 (MESH:D002245), AMES (MESH:C017501), vegetable oil (MESH:D010938), CAR (MESH:C024714), alpha-humulene (MESH:C042686), soy oil (MESH:D013024), beta-copaene (MESH:C000629769), hydrochloric acid (MESH:D006851), Sesquiterpenes (MESH:D012717), phenolphthalein (MESH:D020113), sodium lauryl sulfate (MESH:D012967) - **Species:** Glycine max (soybean, species) [taxon 3847], Rattus norvegicus (brown rat, species) [taxon 10116], Staphylococcus aureus (species) [taxon 1280], Mus musculus (house mouse, species) [taxon 10090], Staphylococcus haemolyticus (species) [taxon 1283], Copaifera langsdorffii (copaiba, species) [taxon 280048], Streptococcus pneumoniae (species) [taxon 1313], Copaifera martii (species) [taxon 2743242], Enterococcus faecalis (species) [taxon 1351], Staphylococcus epidermidis ATCC 12228 (strain) [taxon 176280], Staphylococcus epidermidis (species) [taxon 1282], Bacillus subtilis (species) [taxon 1423], Homo sapiens (human, species) [taxon 9606] - **Mutations:** C-300 C, C-200 C, (TTC) at 5 - **Cell lines:** RAW 264.7 — Mus musculus (Mouse), Mouse leukemia, Cancer cell line (CVCL_0493), A549 — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_0023), RPMI-8226 — Homo sapiens (Human), Plasma cell myeloma, Cancer cell line (CVCL_0014), Hek293 — Homo sapiens (Human), Transformed cell line (CVCL_0045) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12993705/full.md ## Figures 7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12993705/full.md ## References 62 references — full list in the complete paper: https://tomesphere.com/paper/PMC12993705/full.md --- Source: https://tomesphere.com/paper/PMC12993705