# Insights into human respiratory microbiome under dysbiosis and its analysis tool

## TL;DR

This paper explores the human respiratory microbiome and its role in health and disease, focusing on how microbial imbalances affect lung conditions.

## Contribution

The study provides an overview of current techniques and understanding of microbiota-lung disease relationships.

## Key findings

- The respiratory microbiome is influenced by microbial immigration and removal.
- Recent sequencing techniques have improved microbial community analysis.
- Bacterial co-occurrence is linked to interactions with fungi and host factors.

## Abstract

The human respiratory tract microbiome is a multi-kingdom microbial ecology that inhabits several habitats along the respiratory tract. The respiratory tract microbiome promotes host health by strengthening the immune system and avoiding pathogen infection. The lung microbiome mostly originates in the upper respiratory tract. The balance between microbial immigration and removal determines the nature of the lung microbiome. Identification and characterization of microbial communities from airways have been made much easier by recent developments in amplicon and shotgun metagenomic sequencing and data analysis techniques. In pulmonary medicine, there is a growing interest in the respiratory microbiome, which has been linked to human health and illness. However, the primary causes of bacterial co-occurrence seem to be interactions with fungi and bacteria as well as host and environmental factors. This study focused on identifying techniques and the current understanding of the relationship between the microbiota and various lung diseases.