# Carotid endarterectomy with active extracorporeal perfusion for bilateral ocular ischemic syndrome in a patient with a preoperatively defined critical single-vessel cerebral supply on four-dimensional flow magnetic resonance imaging

**Authors:** Johan Millinger, Isabella M. Björkman-Burtscher, Anna Corderfeldt Keiller, Elias Johansson, Kerstin Lagerstrand, Joakim Nordanstig

PMC · DOI: 10.1016/j.jvscit.2026.102180 · Journal of Vascular Surgery Cases, Innovations and Techniques · 2026-02-12

## TL;DR

A patient with severe carotid artery disease and vision-threatening eye issues underwent a specialized surgery to protect the brain during carotid surgery.

## Contribution

Demonstrates the use of 4D flow MRI and extracorporeal perfusion in managing complex carotid cases.

## Key findings

- 4D flow MRI identified critical left carotid system as the main cerebral blood source.
- Extracorporeal perfusion was used during surgery to prevent brain hypoperfusion.
- Case shows successful neuroprotection in high-risk carotid revascularization.

## Abstract

Ocular ischemic syndrome is a rare manifestation of severe carotid artery occlusive disease with risk of vision loss. We report a patient with bilateral ocular ischemic syndrome secondary to advanced atherosclerosis, including brachiocephalic and subclavian artery occlusions and high-grade bilateral carotid stenosis. Four-dimensional flow magnetic resonance imaging demonstrated near-exclusive cerebral perfusion derived from the left carotid system. Carotid endarterectomy was performed using extracorporeal veno-arterial antegrade selective cerebral perfusion for neuroprotection, as standard shunting was deemed inadequate. This case highlights the utility of four-dimensional flow magnetic resonance imaging in identifying hypoperfusion risk and the utility of extracorporeal cerebral perfusion in complex carotid revascularization.

## Linked entities

- **Diseases:** atherosclerosis (MONDO:0005311)

## Full-text entities

- **Diseases:** vision loss (MESH:D014786), brachiocephalic and subclavian artery occlusions (MESH:D001157), carotid stenosis (MESH:D016893), carotid artery occlusive disease (MESH:D002340), Ocular ischemic syndrome (MESH:D018917), atherosclerosis (MESH:D050197)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12993385/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12993385/full.md

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Source: https://tomesphere.com/paper/PMC12993385