# Systemic Rasamsonia argillacea infection in a German Shepherd dog

**Authors:** Louisa Schmidt, Sebastian Reusch, Ilka McCormick-Smith, Jasmin Gerkrath, Martin Peters, Volker Rickerts

PMC · DOI: 10.1016/j.mmcr.2026.100779 · Medical Mycology Case Reports · 2026-03-07

## TL;DR

A German Shepherd dog developed a severe infection caused by Rasamsonia argillacea, a fungus known for resistance to antifungal drugs.

## Contribution

This report highlights the clinical challenge of treating azole-resistant R. argillacea infections in veterinary medicine.

## Key findings

- The infection spread to lymph nodes, abdominal organs, and an eye in a German Shepherd.
- Itraconazole treatment failed to halt the progression of the disease.
- The case underscores the increasing threat of azole-resistant fungal infections.

## Abstract

This case report describes a disseminated Rasamsonia (R.) argillacea infection in a German shepherd dog involving internal and external lymph nodes, abdominal organs and one eye. R. argillacea is a member of the R. argillacea species complex, which is an emerging pathogen notable for azole resistance in the last decades. The dog was euthanised following 18 days of itraconazole therapy due to clinical deterioration.

## Linked entities

- **Chemicals:** itraconazole (PubChem CID 55283)
- **Species:** Canis lupus familiaris (taxon 9615)

## Full-text entities

- **Diseases:** Rasamsonia (R.) argillacea infection (MESH:D007239)
- **Chemicals:** itraconazole (MESH:D017964), azole (MESH:D001393)
- **Species:** Canis lupus familiaris (dog, subspecies) [taxon 9615], Rasamsonia argillacea (species) [taxon 69808]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12993233/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12993233/full.md

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Source: https://tomesphere.com/paper/PMC12993233