# Results of the epidemiological measurement of endemics, epidemics, and pandemics

**Authors:** Fabian Standl, Dominik Stelzle, Mirko Trilling, Philipp Jansen, Heribert Stich, Andreas Stang

PMC · DOI: 10.1016/j.idm.2026.02.003 · Infectious Disease Modelling · 2026-02-28

## TL;DR

This study introduces a framework to compare epidemic wave patterns across outbreak types using a metric called Duty Cycle, revealing differences in wave dynamics between endemics, epidemics, and pandemics.

## Contribution

A novel descriptive framework using Duty Cycle to quantify and compare epidemic wave characteristics across outbreak scales and pathogens.

## Key findings

- Endemics and epidemics show higher Duty Cycle values, indicating overlapping waves, while pandemics have lower Duty Cycle and fewer subsequent waves.
- Pandemics typically peak in the second wave and show waning, whereas subsequent waves in endemics and epidemics often exceed the first wave.
- Wave-peak postdiction accuracy varies across outbreak types, reflecting perspective-dependent uncertainty in wave definitions.

## Abstract

Reliable characterization of infection dynamics is critical for managing endemic, epidemic, and pandemic outbreaks. A persistent challenge in epidemiology is the lack of a unified quantitative framework that allows wave patterns to be compared across outbreak scales and pathogens while accounting for possible ambiguities in wave definitions. This study presents a descriptive epidemiological framework to quantify epidemic wave characteristics using the Duty Cycle (DC), defined as the ratio between wave duration and the time to the next peak. Historical time-series data from viral outbreaks were analyzed, and combinatorics was applied to consider all valid interpretations (“perspectives”) of wave boundaries within the same incidence curves, thereby avoiding a perspective-selection bias. We calculated DC values, wave peak postdiction accuracy in days, wave heights relative to initial peaks, and subsequent wave frequencies. Distribution-based analyses show that DC values are generally higher in endemics and epidemics, indicating frequent overlapping waves, whereas pandemics tend to exhibit lower DC and fewer subsequent waves. Wave-peak postdiction accuracy varied across outbreak scales, with distributions reflecting perspective-dependent uncertainty. While subsequent waves of infection in endemics and epidemics are frequently higher than the first wave, pandemics typically peaked in the second wave and showed waning thereafter. The results provide a comparative, structurally grounded description of epidemic wave dynamics across outbreak types, supporting outbreak assessment and planning. Given the heterogeneity of reporting and outbreak dynamics, results should be interpreted as descriptive benchmarks rather than mechanistic postdictions.

## Full-text entities

- **Diseases:** infection (MESH:D007239)

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12992935/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12992935/full.md

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Source: https://tomesphere.com/paper/PMC12992935