# A comprehensive treatment analysis of primary squamous cell carcinoma of the prostate with inguinal lymph node metastasis: a case report and literature review

## TL;DR

This paper presents a case of rare primary prostate squamous cell carcinoma with inguinal lymph node metastasis, highlighting treatment strategies and outcomes.

## Contribution

The paper provides a detailed case report and literature review on a rare prostate cancer subtype with metastasis.

## Key findings

- The patient showed good tolerance to chemotherapy and radiotherapy with lesion size reduction.
- Early radical surgery combined with chemotherapy and radiotherapy may prolong survival in prostatic SCC.
- Prostatic SCC shows poor response to endocrine therapy.

## Abstract

Primary squamous cell carcinoma(SCC) of the prostate is a rare clinical condition, characterized by diagnostic challenges in the early stages, a high potential for metastasis, considerable malignancy, and a poor prognosis. Reporting such cases may contribute to a better understanding of the pathogenesis and clinical manifestations of prostatic SCC, as well as facilitate the exploration of diagnostic approaches and effective treatment strategies.

A retrospective analysis was conducted on the clinical case of a 62-year-old male patient with primary prostatic SCC and concurrent inguinal lymph node metastasis, admitted to our institution. The diagnosis was confirmed by histopathological examination following fine-needle aspiration biopsy. The patient underwent two cycles of intravenous chemotherapy, followed by radical surgical resection and adjuvant radiotherapy. By integrating findings from this case with current literature, this study aims to elucidate the etiology, clinical manifestations, diagnostic strategies, therapeutic modalities, and prognostic factors associated with this rare malignancy.

The patient demonstrated good tolerance to both chemotherapy and radiotherapy, with a significant reduction in lesion size observed following treatment. After comprehensive management including surgical resection, the patient has remained alive for nearly two years of continuous follow-up. Notably, prostatic SCC exhibits poor responsiveness to endocrine therapy. The most effective therapeutic approach involves early radical surgery, which, when integrated with chemotherapy, radiotherapy, and other modalities, may contribute to prolonged survival.