# Enhanced Effectiveness of Onabotulinum Toxin A in Combination With Definisse KP1 Eye Contour Cream for Upper Face Rejuvenation: A Case Series

## TL;DR

Combining onabotulinum toxin A injections with a specific eye cream improved upper face rejuvenation and skin quality more than using the toxin alone.

## Contribution

Demonstrates enhanced effectiveness of combining onabotulinum toxin A with a bioactive peptide cream for upper face rejuvenation.

## Key findings

- The +KP1 group showed improvement in all variables except for eye erythema and oedema.
- The Control group only improved in eye impairment severity and periocular wrinkles.
- Subjects in the +KP1 group reported higher satisfaction with the treatment protocol.

## Abstract

Among antiaging treatments, botulin toxin A injection is one of the most widely used. KP1 (Serpine A1‐III) is a recently developed bioactive peptide that increases collagen type I by enhancing its synthesis and preventing its degradation.

This case series described the combinatorial effect of onabotulinum toxin A injection with Definisse KP1 eye contour cream application in the treatment of skin aging in the upper third of the face.

Adult subjects with moderate to severe dynamic wrinkles who received onabotulinum toxin A combined with Definisse KP1 eye contour cream (Onabotulinum toxin A + KP1 group, hereinafter referred to as + KP1 group) or onabotulinum toxin A alone (Control group) were included in the analysis. The following variables were measured: severity of the disorder, skin hypersensitivity, erythema, oedema, periocular wrinkles, skin quality, hydration‐creepiness, and tightness; each parameter was evaluated in both eyes 4 weeks posttreatment.

Data from 22 in the + KP1 group and 19 in the Control group were collected. In the + KP1 group, all variables improved, except for eye erythema and eye oedema. Conversely, in the Control group, only eye impairment severity and periocular wrinkles improved from baseline. In the satisfaction questionnaire, the overall evaluation of the protocol achieved higher scores in the + KP1 group than in the Control group.

From this case series, the application of Definisse KP1 eye contour cream seems to enhance the effect of onabotulinum toxin A injection on periocular wrinkles and provide additional benefits in skin quality; the combined procedure was tolerated, feasible, and appreciated by subjects.