# A novel pace-mapping technique for Isthmus Identification in Non-Sustained Uncommon Atrial Flutter Pacing Technique: the INPACT method—a case report

**Authors:** Daisuke Munakata, Takeshi Ueyama, Tomoyuki Uchida, Yasuhiro Ikeda

PMC · DOI: 10.1093/ehjcr/ytag139 · European Heart Journal. Case Reports · 2026-03-03

## TL;DR

A new pacing technique called INPACT helps identify critical areas in non-sustained atrial flutter without needing the arrhythmia to persist during mapping.

## Contribution

The INPACT method introduces a novel pace-mapping approach using an isthmus ratio metric for non-sustained atrial flutter.

## Key findings

- The INPACT method successfully identified the critical isthmus in a patient with non-sustained atrial flutter.
- Radiofrequency ablation at the highest isthmus ratio site eliminated the tachycardia with no recurrence after 6 months.
- The technique uses iPASO technology and systematic pace-mapping during sinus rhythm to overcome limitations of conventional mapping.

## Abstract

Mapping uncommon atrial flutter (AFL) remains challenging when tachycardia cannot be sustained during the procedure. We developed a novel pace-mapping methodology for identifying critical isthmuses in non-sustained uncommon AFL circuits during sinus rhythm.

A 70-year-old male presented with persistent AFL (cycle length 370 ms) following mitral valve repair with concomitant surgical pulmonary vein isolation. During electrophysiological study, the tachycardia terminated spontaneously, precluding conventional mapping. We implemented the Isthmus Identification in Non-Sustained Uncommon Atrial Flutter PACing Technique (INPACT), combining Intracardiac Pattern-match ScOring (iPASO) technology with systematic pace-mapping during sinus rhythm. A novel isthmus ratio (IR) metric differentiated potential isthmus sites among those with high morphological correlation (iPASO ≥90%). The critical isthmus was identified within a low-voltage area adjacent to the atrial septotomy line. Radiofrequency ablation targeting the site with the highest IR value eliminated the tachycardia with no recurrence at 6-month follow-up.

The INPACT enables identification of critical isthmuses without requiring sustained tachycardia, offering a solution for challenging cases where conventional mapping is limited by non-sustained arrhythmia. This approach may improve procedural efficiency and outcomes in complex uncommon AFL.

## Linked entities

- **Diseases:** atrial flutter (MONDO:0005310)

## Full-text entities

- **Diseases:** ventricular tachycardia (MESH:D017180), arrhythmia (MESH:D001145), atrial tachycardia (MESH:D013617), tachycardia (MESH:D013610), atrial scarring (MESH:D002921), AFL (MESH:D001282)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12989645/full.md

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Source: https://tomesphere.com/paper/PMC12989645