# Vimentin Intermediate Filaments: A Paradigm Shift From Static Structure to Dynamic Cytoplasmic Network

## TL;DR

This paper reviews how vimentin intermediate filaments are dynamic structures that interact with other cytoskeletal components to influence cell mechanics and organization.

## Contribution

The paper introduces a hybrid transport model to explain vimentin filament dynamics through cytoskeletal crosstalk and organelle transport.

## Key findings

- Vimentin intermediate filaments form a dynamic network that interacts with microfilaments and microtubules.
- VIFs coordinate cytoskeletal architecture and facilitate organelle positioning.
- VIFs act as dynamic integrators of intracellular logistics and cell mechanics.

## Abstract

Recent advances in live‐cell imaging, super‐resolution microscopy, labeling techniques and cryo‐electron microscopy reveal vimentin intermediate filaments (VIFs) as adaptable polymers that couple mechanical stability with rapid remodeling. In this review, we highlight recent findings and discuss how VIFs function as dynamic, interpenetrating networks with actin microfilaments and microtubules, coordinating cytoskeletal architecture while simultaneously facilitating organelle positioning and influencing cellular behavior. We also propose a hybrid transport model to capture the diverse modes of VIF cellular interactions. This emerging framework positions VIFs as dynamic integrators of cytoskeletal organization and intracellular logistics, with broad implications for understanding cell mechanics, migration, and disease.

Vimentin intermediate filaments form a dynamic, motile network that interacts with microfilaments and microtubules. We propose a hybrid transport model to explain vimentin filament dynamics through cytoskeletal crosstalk and organelle‐associated transport. Thus, intermediate filaments are an active coordinator of cell mechanics, migration, and intracellular organization.