# Lamins’ role in osteosarcoma

## TL;DR

This paper reviews how lamins, proteins in the nucleus, may influence osteosarcoma, a type of aggressive bone cancer.

## Contribution

The paper provides a comprehensive review of lamins' emerging role in bone cancer biology and mechanotransduction.

## Key findings

- Lamins are essential components of the inner nuclear membrane and play a role in mechanosensing.
- Lamins influence bone cell differentiation and are linked to mechanotransduction processes.
- The paper highlights gaps in understanding lamins' role in osteosarcoma biology.

## Abstract

Osteosarcoma (OS) is a rare and highly aggressive bone tumor that can develop in several skeletal segments, although it predominantly affects the long bones. This cancer mostly occurs in adolescents, young adults and people older than 60. There are many questions still open regarding osteosarcoma biology and the efficacy of current treatments. Recent research has increasingly emphasized the critical role of mechanotransduction as a key regulator of cellular functions. Notably, emerging evidence highlights the nucleus as an active player in mechanosensing and mechanotransduction processes within the bone tissue. The nuclear envelope is composed of several proteins, among which lamins. These proteins are essential components of the inner nuclear membrane (INM) exerting many different functions, also known for having a pivotal role in mechanotransduction and bone cell differentiation. In this review, we analyze the state of the art regarding the lamins role in bone cancer biology.