# A combination of cognitive behavioral therapy and enteral nutrition support is beneficial for patients with severe acute pancreatitis in intensive care unit

**Authors:** Jingyi Chen, Kaibing Xiao, Xiangyu Tong, Xia Zhao

PMC · DOI: 10.3389/fmed.2026.1721923 · Frontiers in Medicine · 2026-03-02

## TL;DR

Combining cognitive behavioral therapy with enteral nutrition improves outcomes for severe acute pancreatitis patients in the ICU.

## Contribution

This study demonstrates the benefits of combining CBT with enteral nutrition for SAP patients in the ICU.

## Key findings

- The study group showed improved blood biochemical indicators and reduced inflammatory markers.
- Patients in the study group had shorter ICU and hospital stays and higher quality of life scores.

## Abstract

This study aimed to assess the effects of cognitive behavioral therapy (CBT) combined with enteral nutrition support on patients with severe acute pancreatitis (SAP) in the intensive care unit (ICU). From May 2022 to August 2023, 50 SAP patients admitted to our hospital were randomly assigned to a control group (routine nursing) and a study group (CBT nursing based on routine nursing). Both groups received enteral nutrition support. After 14 days of intervention, the study group showed higher blood biochemical indicators (albumin, total protein, globulin) and lower inflammatory marker levels (procalcitonin, C-reactive protein, interleukin-6) compared to the control group. The study group also had shorter ICU and hospital stays, quicker resumption of oral feeding, lower pain scores, and higher quality of life scores. No significant differences in gastrointestinal adverse reactions and infections were observed between the two groups. We concluded that CBT combined with enteral nutrition support benefits SAP patients in the ICU by improving nutritional status, reducing inflammation, relieving pain, and enhancing quality of life.

## Linked entities

- **Proteins:** LOC100189571 (uncharacterized LOC100189571), LOC541927 (globulin 3), IL6 (interleukin 6)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** gastrointestinal adverse reactions (MESH:D005767), pain (MESH:D010146), infections (MESH:D007239), inflammation (MESH:D007249), SAP (MESH:D045169)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12989484/full.md

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Source: https://tomesphere.com/paper/PMC12989484