# Long Term Metabolic Outcomes Following Pancreatectomy and Autologous Islet Transplantation: Systematic Review and Meta‐Analysis

## TL;DR

This study reviews long-term results of a surgery that removes the pancreas and transplants its islets, showing mixed success in maintaining insulin independence.

## Contribution

The study provides a meta-analysis of long-term metabolic outcomes after TPIAT, highlighting differences based on surgical indication.

## Key findings

- The pooled insulin independence rate after TPIAT was 34%.
- Patients without chronic pancreatitis had higher insulin independence rates (68%) compared to those with chronic pancreatitis (33%).
- TPIAT is effective in preserving endocrine function, but more research is needed for broader validation.

## Abstract

This systematic review and meta‐analysis assessed long‐term outcomes following total pancreatectomy with islet autotransplantation (TPIAT). Seventeen studies including 1332 patients were analyzed. The pooled insulin independence rate was 34%, with higher rates for non‐chronic pancreatitis indications (68%) versus chronic pancreatitis (33%). TPIAT is effective in preserving endocrine function. Further studies are needed to validate outcomes across extended indications and to standardize reporting, incorporating metabolic markers and patient‐reported quality‐of‐life endpoints over long‐term follow‐up.