# Referred Pain Manifestation and Its Impact on Patients With Temporomandibular Disorder

**Authors:** Beatriz Amaral de Lima‐Netto, Paulo César Rodrigues Conti, Rafaela Stocker Salbego, Matheus Herreira‐Ferreira, Yuri Martins Costa, Leonardo Rigoldi Bonjardim

PMC · DOI: 10.1111/odi.70021 · Oral Diseases · 2025-07-21

## TL;DR

This study shows that more referred pain sites in TMD patients are linked to higher pain levels and worse overall health, offering a new way to assess severity.

## Contribution

The study identifies predictors of referred pain sites and their association with pain severity in TMD patients.

## Key findings

- More referred pain sites correlate with higher pain intensity, frequency, and more painful body sites.
- Each additional day of pain and each additional painful body site predict increased referred pain sites.
- Assessing referred pain sites can help evaluate TMD severity more comprehensively.

## Abstract

To investigate whether a higher number of sites eliciting referred pain upon palpation is associated with greater impairment in biopsychosocial aspects in TMD patients and identify variables that predict increased referred pain.

This cross‐sectional study analyzed data from 77 women with myalgia, assessing the number of sites eliciting referred pain upon palpation in relation to clinical (duration, frequency, intensity, painful body sites, pain‐related disability), psychological (stress, anxiety, depression, catastrophizing, sleep quality), and psychophysical variables (mechanical and pressure pain thresholds, temporal summation and conditioned pain modulation).

Spearman's correlation revealed a significant correlation between the number of sites eliciting referred pain upon palpation in the orofacial region and both pain intensity and frequency (p < 0.001), as well as with the number of painful body sites (p = 0.009). Negative binomial regression indicated that each additional day of pain in the past week and each additional painful body site were predictors of increases of 10% and 4%, respectively, in the number of sites eliciting referred pain upon palpation.

These findings highlight the utility of assessing referred pain sites as a complementary indicator of severity in clinical pain parameters, providing a practical and effective tool for a more comprehensive evaluation of patients.

## Full-text entities

- **Diseases:** Temporomandibular Disorder (MESH:D013705), TMD (MESH:D049310), depression (MESH:D003866), myalgia (MESH:D063806), anxiety (MESH:D001007), Pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12989051/full.md

## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12989051/full.md

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Source: https://tomesphere.com/paper/PMC12989051