# Müller-Weiss Syndrome: A Case Report and Review of the Literature

**Authors:** Wissal Belhadj, Laila Taoubane, Imane Mohammadine, Abderrahim Majjad, Ahmed Bezza

PMC · DOI: 10.7759/cureus.103486 · Cureus · 2026-02-12

## TL;DR

This paper reports a case of Müller-Weiss syndrome, a rare condition causing midfoot pain due to navicular bone damage.

## Contribution

The study adds a new clinical case to the limited literature on Müller-Weiss syndrome and confirms conservative treatment effectiveness.

## Key findings

- A 60-year-old woman presented with chronic midfoot pain consistent with Müller-Weiss syndrome.
- Imaging confirmed navicular bone changes typical of the syndrome.
- Conservative treatment led to favorable clinical outcomes.

## Abstract

Müller-Weiss syndrome is a rare condition characterized by osteonecrosis of the navicular bone. We describe the case of a 60-year-old woman presenting with chronic, non-traumatic mechanical pain of the right midfoot. Laboratory investigations, including inflammatory markers, were within normal limits. Weight-bearing radiographs and CT demonstrated changes of the navicular bone consistent with Müller-Weiss syndrome. This diagnosis was considered in the context of persistent mechanical midfoot pain, and the patient was managed conservatively, with favorable clinical evolution during follow-up .

## Full-text entities

- **Diseases:** inflammatory (MESH:D007249), osteonecrosis of the navicular bone (MESH:C536002), Muller-Weiss Syndrome (MESH:C537559), midfoot pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12988827/full.md

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Source: https://tomesphere.com/paper/PMC12988827