# Clostridium perfringens Bacteremia Secondary to Stercoral Colitis in a Patient With Advanced Parkinson’s Disease: A Rare Case Report

**Authors:** Nidhay Prakashkar, Jaskaran Singh, Shreya Muralidharan, Cheyenne Moffett, Sorabh Sharma

PMC · DOI: 10.7759/cureus.103471 · Cureus · 2026-02-12

## TL;DR

A rare case of Clostridium perfringens bacteremia caused by stercoral colitis in a patient with Parkinson's disease is reported, emphasizing the importance of early treatment.

## Contribution

This case report highlights stercoral colitis as a rare source of C. perfringens bacteremia without perforation or soft tissue infection.

## Key findings

- C. perfringens bacteremia was diagnosed in a patient with stercoral colitis and no soft tissue infection.
- Treatment with metronidazole and bowel management led to stable recovery in a high-risk patient.
- Stercoral colitis can be a source of C. perfringens bacteremia, even without intestinal perforation.

## Abstract

Clostridium perfringens infections are often associated with high mortality and typically result from soft tissue infections. Stercoral colitis, a complication of fecal infection, is more frequently linked to gram-negative bacteremia. We present a rare case of C. perfringens bacteremia caused by stercoral colitis. A 62-year-old woman with advanced Parkinson's disease, dementia, and immobility presented with altered mental status. Stroke was ruled out. Blood cultures grew C. perfringens without signs of soft tissue infection. A CT of the abdomen showed stercoral colitis with fecal impaction. She was treated with a seven-day course of intravenous metronidazole and an aggressive bowel regimen. She remained hemodynamically stable and was discharged in stable condition for outpatient follow-up. This case highlights stercoral colitis as a potential source of C. perfringens bacteremia even without perforation or soft tissue involvement. Early antibiotics, bowel decompression, and nutritional support can improve outcomes in high-risk patients.

## Linked entities

- **Chemicals:** metronidazole (PubChem CID 4173)
- **Diseases:** Parkinson’s disease (MONDO:0005180), dementia (MONDO:0001627)
- **Species:** Clostridium perfringens (taxon 1502)

## Full-text entities

- **Diseases:** Stercoral Colitis (MESH:D003092), fecal impaction (MESH:D005244), dementia (MESH:D003704), Parkinson's Disease (MESH:D010300), infection (MESH:D007239), Stroke (MESH:D020521), bacteremia (MESH:D016470), fecal infection (MESH:D005242), Clostridium perfringens Bacteremia (MESH:D003015)
- **Chemicals:** metronidazole (MESH:D008795)
- **Species:** Clostridium perfringens (species) [taxon 1502], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12988768/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12988768/full.md

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Source: https://tomesphere.com/paper/PMC12988768