# A case of high-grade differentiated liposarcoma in the oesophagus

**Authors:** Hongyang Li, Hui Huang, Ting Zhao, Zhuoya Ma, Licui Zhang, Yong Wen, Qinghong Duan

PMC · DOI: 10.1093/bjrcr/uaaf068 · BJR | Case Reports · 2025-12-26

## TL;DR

This paper reports a rare case of high-grade liposarcoma in the oesophagus to improve awareness and reduce misdiagnosis.

## Contribution

The novelty lies in presenting a rare case of high-grade, well-differentiated liposarcoma in the oesophagus.

## Key findings

- Liposarcoma is often misdiagnosed due to nonspecific symptoms and lack of standardized treatment.
- The case highlights the importance of recognizing imaging features to avoid missed diagnoses.

## Abstract

Liposarcoma is a rare malignancy that is typically amenable to surgical resection if there are no distant metastases.1 However, it has a high degree of misdiagnosis. The primary differential diagnoses are sarcoma, gastrointestinal stromal tumour (GIST), and fibrovascular polyp.2 The diagnosis and management of liposarcoma remain challenging due to its lack of specific clinical symptoms and the absence of standardized and effective treatment protocols. Here, we present a case of high-grade, well-differentiated liposarcoma of the oesophagus. It is hoped that this report will increase awareness of the imaging features of this rare neoplasm among radiologists and clinicians, thereby reducing the likelihood of missed diagnoses.

## Linked entities

- **Diseases:** liposarcoma (MONDO:0003585)

## Full-text entities

- **Genes:** MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}, ANO1 (anoctamin 1) [NCBI Gene 55107] {aka DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, VIM (vimentin) [NCBI Gene 7431], MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, CDK4 (cyclin dependent kinase 4) [NCBI Gene 1019] {aka CMM3, MCPH31, PSK-J3}, DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, SOX10 (SRY-box transcription factor 10) [NCBI Gene 6663] {aka DOM, PCWH, SOX-10, WS2E, WS4, WS4C}, S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, CALD1 (caldesmon 1) [NCBI Gene 800] {aka CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22}, CD34 (CD34 molecule) [NCBI Gene 947]
- **Diseases:** malignancy (MESH:D009369), weight loss (MESH:D015431), Primary (MESH:D010538), metastases.1 (MESH:D009362), Polyps (MESH:D011127), bleeding (MESH:D006470), sarcoma (MESH:D012509), infective (MESH:D007239), GIST (MESH:D046152), chest pain (MESH:D002637), dysphagia (MESH:D003680), Liposarcomas (MESH:D008080), vomiting (MESH:D014839), dyspnea (MESH:D004417), oesophageal lesion (MESH:D000077277), pain (MESH:D010146), fatty (MESH:D008067)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12988589/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12988589/full.md

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Source: https://tomesphere.com/paper/PMC12988589