# Myxoid liposarcoma of the leg: a case report

**Authors:** Angelo Montana, Gabriele Mirabella, Giambattista Privitera, Stefano Bastoni, Antonina Parafioriti, Placido Romeo

PMC · DOI: 10.1093/bjrcr/uaaf055 · BJR | Case Reports · 2025-11-18

## TL;DR

This paper reports a case of myxoid liposarcoma in the leg, highlighting the challenges in diagnosis and the need for combined imaging and histology.

## Contribution

The paper presents a specific case report emphasizing the diagnostic challenges and management of myxoid liposarcoma in the leg.

## Key findings

- Myxoid liposarcoma is challenging to diagnose using imaging alone due to its CT and MRI characteristics.
- A combination of imaging techniques and histological analysis is necessary for accurate diagnosis and preoperative planning.
- The tumor in this case originated from the intermuscular fascial planes of the anterior leg compartment.

## Abstract

Myxoid liposarcoma is the second most frequent subtype of liposarcoma, affecting predominantly the extremities, as seen in our case report. Diagnosing myxoid liposarcoma using imaging can be challenging due to its characteristics on both CT and MRI; for this reason, a combination of imaging techniques and histological patterns is necessary to accurately assess the tumour and subsequently make a preoperative planning. We present a case of myxoid liposarcoma arising from the intermuscular fascial planes of the anterior compartment of the leg.

## Linked entities

- **Diseases:** myxoid liposarcoma (MONDO:0013280)

## Full-text entities

- **Genes:** MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, DDIT3 (DNA damage inducible transcript 3) [NCBI Gene 1649] {aka AltDDIT3, C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10}, CDK4 (cyclin dependent kinase 4) [NCBI Gene 1019] {aka CMM3, MCPH31, PSK-J3}, CD34 (CD34 molecule) [NCBI Gene 947]
- **Diseases:** Tumours (MESH:D009369), malignant mesenchymal tumours (MESH:C535700), metastases (MESH:D009362), tenderness (MESH:D063806), cyst (MESH:D003560), benign cystic tumours (MESH:D018297), Myxoid liposarcoma (MESH:D018208), trauma (MESH:D014947), myxoid (MESH:D045888), liposarcomatous mass (MESH:C536030), soft tissue neoplasms (MESH:D012983), Liposarcomas (MESH:D008080), cystic lesions (MESH:D052177), necrosis (MESH:D009336), lipoma (MESH:D008067)
- **Chemicals:** STIR (-), Fat (MESH:D005223), water (MESH:D014867), Hematoxylin (MESH:D006416), gadolinium (MESH:D005682)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12988588/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12988588/full.md

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Source: https://tomesphere.com/paper/PMC12988588