# Filling the treatment gaps in osteoporosis: osteoimmunology as a new frontier

**Authors:** eBioMedicine

PMC · DOI: 10.1016/j.ebiom.2026.106221 · eBioMedicine · 2026-03-11

## Full-text entities

- **Genes:** Il17a (interleukin 17A) [NCBI Gene 301289] {aka CTLA-8, IL-17, IL-17A, Il17}, Il6 (interleukin 6) [NCBI Gene 24498] {aka ILg6, Ifnb2}, Tnfsf11 (TNF superfamily member 11) [NCBI Gene 117516] {aka ODF, OPGL, RANKL, TRANCE}, Tnf (tumor necrosis factor) [NCBI Gene 24835] {aka RATTNF, TNF-alpha, Tnfa}
- **Diseases:** inflammatory bone loss (MESH:D016301), osteoporotic vertebral fractures (MESH:D058866), bone loss (MESH:D001847), toxicity (MESH:D064420), cancer (MESH:D009369), autoimmune disorders (MESH:D001327), inflammatory (MESH:D007249), fracture (MESH:D050723), osteoporosis (MESH:D010024)
- **Chemicals:** manganese (MESH:D008345), Denosumab (MESH:D000069448), teriparatide (MESH:D019379), short chain fatty acids (MESH:D005232)
- **Species:** gut metagenome (species) [taxon 749906], Clostridium butyricum (species) [taxon 1492], Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

## Full text

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Source: https://tomesphere.com/paper/PMC12988544