# Genome architecture: nuclear context links noncoding variants to transcriptional programs

**Authors:** Assam El-Osta

PMC · DOI: 10.1038/s41392-026-02616-5 · Signal Transduction and Targeted Therapy · 2026-03-12

## Full-text entities

- **Genes:** EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) [NCBI Gene 2146] {aka ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS}, CTCF (CCCTC-binding factor) [NCBI Gene 10664] {aka CFAP108, FAP108, MRD21}, PPRC1 (PPARG related coactivator 1) [NCBI Gene 23082] {aka PRC}, TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor) [NCBI Gene 6886] {aka SCL, TCL5, bHLHa17, tal-1}, RNF2 (ring finger protein 2) [NCBI Gene 6045] {aka BAP-1, BAP1, DING, HIPI3, LUSYAM, RING1B}
- **Diseases:** immune dysregulation (OMIM:614878), cancer (MESH:D009369), developmental disorders (MESH:D002658)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** H1 — Homo sapiens (Human), Induced pluripotent stem cell (CVCL_HA53)

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Source: https://tomesphere.com/paper/PMC12987943