# Reframing Eczema: Th2-Skewed Contact Sensitization, Atopy Patch Testing, and Systemic Contact Dermatitis

## TL;DR

This paper explores how Th2-skewed allergic reactions contribute to eczema and suggests allergen avoidance could reduce the need for systemic treatments.

## Contribution

Highlights Th2-skewed contact sensitization in eczema and proposes atopy patch testing as a diagnostic alternative to systemic therapies.

## Key findings

- Th2-skewed ACD is linked to atopic and systemic contact dermatitis, often triggered by weak allergens or food proteins.
- Atopy patch testing may better identify allergens than IgE-based tests for non-sensitizers.
- Avoiding specific allergens could reduce systemic therapy use in eczema patients.

## Abstract

We review allergic contact dermatitis (ACD) with predominant Th2 type cytokine expression in the context of chronic cutaneous inflammation. While more has been written about Th1 skewed ACD due to potent allergens in the setting of healthy skin, this review highlights recognition of Th2 skewed ACD in both atopic dermatitis and systemic contact dermatitis and the role of allergen avoidance as an alternative to systemic therapies.

Th2 skewed ACD rarely occurs to potent allergens. It more commonly occurs in response to allergens considered “non-sensitizers” in the local lymph node assay. These sensitizers include weaker allergens (e.g. propylene glycol), larger molecules (e.g. food proteins) and commensal micro-organisms. Importantly, group 2 innate lymphoid cells and natural killer T cells may contribute to these cutaneous memory responses without education of Th2 cells in the local lymph node and without downstream antigen-specific IgE. The resulting intrinsic atopic dermatitis may be food-triggered and better diagnosed with atopy patch testing than with tests for antigen specific-IgE used for immediate type hypersensitivity reactions.

Chronic contact, atopic, and stasis dermatitis all occur in the setting of irritant dermatitis and microbial dysbiosis. Both Th1 and Th2 cytokines mediate ACD, although those cytokines may arise from innate immune pathways and not exclusively from T helper cells educated in the local lymph node. More refinement and use of atopy patch tests to identify less potent allergens and dietary avoidance of patient-specific allergens may reduce the number of patients who require systemic therapy for eczema.