# Correction: SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway

**Authors:** Tianyu Wu, Xing Ji, Yongyang Yun, Xiaofei Wang, Ying Gan, Yu Fan, Qian Zhang

PMC · DOI: 10.1371/journal.pone.0345024 · PLOS One · 2026-03-13

## Full-text entities

- **Genes:** MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, SPAG6 (sperm associated antigen 6) [NCBI Gene 9576] {aka CFAP194, CT141, FAP194, Repro-SA-1, pf16}
- **Diseases:** tumor (MESH:D009369), Urogenital Diseases (MESH:D000091642), renal cell carcinoma (MESH:D002292), Urological Cancer (MESH:D014571)

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## References

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Source: https://tomesphere.com/paper/PMC12987482