# Cumulative social adversity as a correlate of self harm: Validity of the Reward Probability Index

**Authors:** Bella Magner-Parsons, Lee Hogarth

PMC · DOI: 10.1371/journal.pone.0326682 · PLOS One · 2026-03-13

## TL;DR

The study validates a questionnaire measuring cumulative social adversity as a risk factor for self-harm and depression.

## Contribution

The Reward Probability Index's environmental adversity subscale is validated as a novel, short measure of cumulative adversity related to self-harm.

## Key findings

- Environmental adversity is strongly associated with increased odds of self-harm.
- Depression, but not anxiety, mediates the link between adversity and self-harm.
- The RPI's environmental adversity subscale correlates with established risk factors like depression and socioeconomic status.

## Abstract

Adversity is a risk factor for Non-Suicidal Self-Injury (NSSI). However, studies differ in their conceptualisation and indices of adversity, creating heterogeneity. The current study sought to validate the environmental adversity (ES) subscale of the Reward Probability Index (RPI) as a correlate of NSSI (and related risk factors: depression, anxiety, and impulsivity) to demonstrate the utility of this short ES questionnaire in self-harm research as a novel measure of cumulative social environmental adversity. A single, cross-sectional, online survey was completed by 149 participants, 50.3% of whom reported past year NSSI engagement. In adjusted models, environmental adversity (OR=3.8), depression (OR=1.1), low subjective socioeconomic status (SES) (OR=1.4) and indirect NSSI (OR=3.7) were associated with an increased odds of past year NSSI engagement. Pearson correlations within the NSSI subsample revealed environmental adversity, depression, and anxiety were associated with each other and NSSI, while impulsivity was not. Finally, a robust parallel mediation analysis indicated that the relationship between environmental adversity and NSSI was mediated by depression β = .165, 95%CI [.033,.336] (R2 = 76.87%), but not anxiety β = .017, 95%CI [−.143,.173] (R2 = 8.07%). These findings are consistent with empirical longitudinal and theoretical evidence proposing NSSI is associated with aversive environmental experience and depression. The finding that the environmental adversity subscale of the RPI is a valid correlate of NSSI, and is associated with other established risk factors for NSSI, validates the ES subscale for use in future longitudinal studies of NSSI as a short general assay of cumulative adversity.

## Linked entities

- **Diseases:** depression (MONDO:0002050), anxiety (MONDO:0005618)

## Full-text entities

- **Genes:** AP2B1 (adaptor related protein complex 2 subunit beta 1) [NCBI Gene 163] {aka ADTB2, AP105B, AP2-BETA, CLAPB1}, CCL16 (C-C motif chemokine ligand 16) [NCBI Gene 6360] {aka CKb12, HCC-4, ILINCK, LCC-1, LEC, LMC}
- **Diseases:** Non (MESH:C580335), Cannabis use (MESH:D002189), Alcohol Use Disorder (MESH:D000437), pain (MESH:D010146), mental health problems (MESH:D000076082), adversity (MESH:D064420), Psychiatric (MESH:D001523), Anxiety Disorder (MESH:D001008), substance use (MESH:D019966), affective disorders (MESH:D019964), sexual assault (MESH:D050035), emotional (MESH:D003072), Impulsiveness (MESH:D007174), executive dysfunction (MESH:D006331), DISH (MESH:D051556), Depression (MESH:D003866), death (MESH:D003643), borderline personality disorder (MESH:D001883), bullying (MESH:D000073397), dysregulation of physical impulses (MESH:D021081), Trauma (MESH:D014947), GAD-7 (MESH:C537955), Anxiety (MESH:D001007), substance misuse (MESH:D009293), physical, emotional, and sexual abuse (MESH:D000082002), alcohol problems (MESH:D019973), Poor appetite (MESH:D001068), social (OMIM:300082), ES (MESH:D018876), NSSI (MESH:D012652), illness (MESH:D002908), overeating (MESH:D006963), physical (MESH:D059445), anxious symptoms (MESH:D012816), mental health (OMIM:603663), skin picking (MESH:D020774)
- **Chemicals:** Alcohol (MESH:D000438), Cannabis Use Disorder (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

93 references — full list in the complete paper: https://tomesphere.com/paper/PMC12987436/full.md

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Source: https://tomesphere.com/paper/PMC12987436