# Global-Token U-Net with Hybrid Loss for Trustworthy Medical Image Super-Resolution

## TL;DR

This paper introduces a new method for medical image super-resolution that improves image quality and reliability by using a hybrid loss function.

## Contribution

The novel hybrid loss combines adversarial and PSNR-based regularization to enhance trustworthiness in medical image super-resolution.

## Key findings

- The hybrid loss function improves high-frequency texture generation in reconstructed images.
- The proposed method maintains high reconstruction quality while increasing trustworthiness.
- Using a global-token U-Net with a lightweight VGG discriminator enhances reliability in medical image super-resolution.

## Abstract

Super-resolution technology significantly enhances the visual quality of low-resolution medical images, resulting in ultra-high-resolution clear images. Super-resolution technology based on artificial intelligence has achieved great success in reconstruction quality. However, like the image restoration task, super-resolution is also an ill-posed problem, and current work lacks consideration of trustworthiness. Medical image super-resolution needs to ensure clarity and, more importantly, to ensure that the output image is reliable and does not produce false details and mislead the diagnosis. To address the trustworthy issue of medical image super-resolution, we design a novel hybrid loss that combines a hinge-based adversarial term with a PSNR-based regularization. In the designed loss function, the adversarial term makes the reconstructed result close to the distribution of the true high-resolution image, thus generating more refined high-frequency textures, while the PSNR-based regularization term explicitly reduces the deviation from the ground truth. We apply this loss in the global-token U-Net backbone network and add a lightweight VGG as the discriminator for adversarial terms. We empirically verify that integrating the proposed methods can enhance the trustworthiness of medical image super-resolution technology while maintaining high reconstruction quality.