# Beyond EDA: A Systematic Review of Multimodal Sympathetic Nervous System Arousal Classification for Stress Detection

**Authors:** Santiago Sosa, Adam K. Fontecchio, Evangelia G. Chrysikou, Jennifer S. Atchison

PMC · DOI: 10.3390/s26051584 · Sensors (Basel, Switzerland) · 2026-03-03

## TL;DR

This paper reviews how combining multiple biosignals improves stress detection by analyzing the sympathetic nervous system.

## Contribution

The paper systematically reviews multimodal approaches to SNS arousal detection, a topic not yet covered in existing literature.

## Key findings

- 58 studies were analyzed to map the evolution from single-signal to multimodal SNS arousal detection.
- Recent advances in signal processing and machine learning enhance multimodal SNS inference.
- The paper identifies open directions for future research in context-aware SNS sensing.

## Abstract

Electrodermal activity (EDA) is a powerful anchor for assessing human sympathetic nervous system (SNS) arousal. However, EDA alone is only one facet of physiological response. Researchers have increasingly moved away from single-sensor analysis to multimodal wearable systems, integrating EDA with other signals such as heart rate variability (HRV), photoplethysmography (PPG), skin temperature (SKT), blood oxygen (SpO2) and more. This critical shift in methodology is not yet reflected in current reviews of the literature. Existing surveys thoroughly cover EDA as a standalone measure, but the combination of sensor technologies has been largely unexamined. In this context, multimodal refers to integrating EDA with complementary biosignals (HRV, PPG, SKT, SpO2, etc.) commonly captured by modern wearable platforms. This review provides a comprehensive analysis focused on multimodal systems for assessing SNS arousal. A total of 58 studies met the inclusion criteria. We map the landscape, from single signal methods to complex sensor-fusion, and highlight advances in multimodal sensor models, physiological modeling, and context-aware sensing. We also examine recent advances in signal processing and machine learning that enhance multimodal SNS arousal inference, outlining current capabilities and identifying open directions for future work. By providing a framework of this emerging field, this paper serves as a resource for all researchers aiming to build and deploy the next generation of context-aware SNS arousal-sensing technology.

## Full-text entities

- **Chemicals:** blood oxygen (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12987280/full.md

## References

68 references — full list in the complete paper: https://tomesphere.com/paper/PMC12987280/full.md

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Source: https://tomesphere.com/paper/PMC12987280