# Inhibition and Mechanisms of Isothiazolinone and Layered Double Hydroxide–Sodium Pyrithione with Modified Hydrophobic Resin Membranes Against Pipeline Moss Fouling

**Authors:** Rudong Zhou, Qifeng Zhao, Aomen Liu, Hui Xu, Yang Xu, Weijie Wang, Jicheng Han, Bo Liu, Muli Wang, Zhigang Di, Lei Miao, Yanhui Liu, Lei Guo

PMC · DOI: 10.3390/polym18050611 · Polymers · 2026-02-28

## TL;DR

This study explores new materials to prevent moss growth in pipelines, focusing on their effectiveness and mechanisms.

## Contribution

A novel composite material combining Isothiazolinone and layered double hydroxide–sodium pyrithione is proposed to inhibit moss while reducing corrosion.

## Key findings

- IS inhibits moss growth effectively at low concentrations and within modified hydrophobic resin membranes.
- LDH-SPT@IS composite improves corrosion resistance while maintaining strong moss inhibition.
- IS disrupts moss DNA and interferes with mitochondrial electron transport.

## Abstract

To address pipeline blockages and corrosion caused by moss, this study evaluates the effectiveness of two treatments, Isothiazolinone (IS) and layered double hydroxide–sodium pyrithione (LDH-SPT) modified hydrophobic resin membranes, in preventing moss growth. Furthermore, we closely examined how IS works at a molecular level to stop moss growth. The sequencing results revealed that the predominant algae identified in the pipeline moss community was a norank species of Trebouxiophyceae, accounting for 75.79%. Tests show that IS has strong moss inhibition. It works at low doses (0.2%) and becomes even more effective as the concentration increases. Furthermore, IS remains highly effective at inhibiting moss within a modified hydrophobic resin membrane, but its corrosion resistance is poor. The LDH-SPT@IS composite modified hydrophobic resin membrane addresses the corrosion problem of using IS alone and still works very well at inhibiting moss. Finally, the mechanism of IS’s inhibition of moss was elucidated based on experiments and existing literature. It functions by disrupting moss cellular DNA structure and interfering with the mitochondrial electron transport chain. This research provides the basis for developing efficient, durable, and eco-friendly solutions to prevent pipeline corrosion and moss growth, paving the way for new technologies and materials.

## Linked entities

- **Chemicals:** sodium pyrithione (PubChem CID 23685289)
- **Species:** Trebouxiophyceae (taxon 75966)

## Full-text entities

- **Chemicals:** IS (MESH:C001490), Sodium Pyrithione (MESH:C008704), LDH-SPT (-)
- **Species:** PX clade (clade) [taxon 569578]

## Full text

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## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12986998/full.md

## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12986998/full.md

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Source: https://tomesphere.com/paper/PMC12986998