# Antioxidant and Neuroprotective Potential of Some Edible Fruits and Vegetable Extracts Based on Comparative Phytochemical Profiling and Bioactivity

## TL;DR

This study compares the antioxidant and neuroprotective effects of extracts from edible fruits and vegetables, finding that they have distinct but complementary health benefits.

## Contribution

The first study to integrate multiple analytical methods to correlate phytochemical profiles with antioxidant and neuroprotective activities in commonly consumed Mediterranean diet foods.

## Key findings

- Plum extract showed the strongest antioxidant capacity due to high chlorogenic and caffeic acids.
- Parsley exhibited the most potent AChE inhibition linked to elevated flavonoids and ferulic/vanillic acids.
- Combined use of these species may support functional foods with synergistic health benefits.

## Abstract

Polyphenols are key dietary bioactive compounds, reducing oxidative stress and neurodegeneration. This study investigated the in vitro antioxidant and neuroprotective potential of some edible fruits (apricots, plums, figs) and vegetable (parsley) extracts related to their phytochemical profile. Plum extract exhibited the strongest antioxidant capacity (ABTS IC50 1.733 ± 0.079 mg/g; DPPH IC50 1.593 ± 0.069 mg/g; FRAP 23.161 ± 1.094 mM Fe2+), linked to its high chlorogenic and caffeic acids content. Parsley displayed the most potent AChE inhibition (IC50 0.825 ± 0.026 mg/g), associated with an elevated flavonoids level (TFC 12.874 ± 0.534 mg QE/g) and the presence of ferulic and vanillic acids. Apricot was characterized by notable gallic, syringic, and chlorogenic acids, supporting moderate neuroprotective potential. Figs showed weaker radical scavenging ability but provided a balanced profile of protocatechuic, caffeic, and syringic acids. Correlation analysis revealed specific compound–activity associations, including syringic and vanillic acids with DPPH scavenging capacity, p-coumaric acid with TPC, and gallic/ferulic acids with AChE inhibition. Effect-directed HPTLC confirmed chlorogenic acid as a major contributor to the antioxidant capacity. To our knowledge, this is the first study to comparatively integrate spectrophotometric antioxidant assays, UHPLC-based quantitative phenolic profiling, effect-directed HPTLC bioautography, and AChE inhibition analysis across three edible fruits and one vegetable frequently co-consumed in Mediterranean-type diets, enabling a cross-species compound–activity correlation framework. These species exhibit distinct but complementary phytochemical and biofunctional profiles. Their combined use may support the formulation of functional foods with synergistic antioxidant and neuroprotective benefits.