Tides of Promise: Sponge-Derived Marine Natural Products in Southeast Asia
Lik Tong Tan, Clarissa Widyantoro, Novriyandi Hanif
TL;DR
This review explores the potential of sponge-derived marine natural products in Southeast Asia for drug discovery, highlighting their diversity and bioactivity.
Contribution
A comprehensive survey and analysis of sponge-derived marine natural products in Southeast Asia over the past two decades.
Findings
Sponges are the dominant source of new marine natural products in Southeast Asia, with Indonesia being the most productive.
SEA sponge metabolites show potent anticancer, antimicrobial, and anti-inflammatory properties.
The South China Sea and Indonesian archipelagos are key bioprospecting hotspots with underexplored regions.
Abstract
Southeast Asia (SEA) harbors one of the world’s richest reservoirs of marine biodiversity, offering immense potential for natural product discovery. This review presents a comprehensive survey of sponge-derived marine natural products (MNPs), with notable activity, reported from SEA over the past two decades, highlighting their chemical diversity, biological activities and regional research trends. Analysis of the past two decades of MNPs data reveals that sponges (Phylum Porifera) remain the dominant source of new MNPs, representing nearly half of all discoveries in the region. Indonesia, Vietnam, and Thailand are leading contributors, with Indonesia exhibiting the highest productivity but limited local research leadership. The South China Sea and Indonesian archipelagos emerge as biodiversity and bioprospecting hotspots, yet large areas remain underexplored. Bioactive metabolites…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsMarine Sponges and Natural Products · Seaweed-derived Bioactive Compounds · Phytochemical compounds biological activities